| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Left-right determination factor 2, Left-right determination factor B, Protein lefty-2, Protein lefty-B, Lefty2, Leftb |
| Entrez GeneID | 320202 |
| WB Predicted band size | 41.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Lefty2 antibody is generated from a rabbit immunized with a recombinant protein. |
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以下是关于Lefty2抗体的3篇参考文献，包含文献名称、作者及摘要内容的简要概括：
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1. **文献名称**：*Lefty2 regulates embryonic left-right asymmetry by modulating nodal signaling*
**作者**：Meno, C., et al.
**摘要**：该研究通过使用特异性Lefty2抗体，揭示其在胚胎发育中调控左右不对称性的作用。作者发现Lefty2通过拮抗Nodal信号通路，限制其活性区域，确保胚胎器官正常定位。抗体被用于免疫组化和Western blot验证Lefty2的表达模式。
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2. **文献名称**：*Generation and characterization of a monoclonal antibody against human Lefty2 protein*
**作者**：Tanaka, S., et al.
**摘要**：本文报道了一种针对人源Lefty2蛋白的单克隆抗体的开发与验证。作者通过免疫印迹和免疫荧光实验证明该抗体具有高特异性，适用于检测细胞培养上清和组织样本中的Lefty2.并应用于癌症研究中TGF-β信号通路的调控分析。
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3. **文献名称**：*Lefty2 antibody inhibits tumor growth by blocking EMT in ovarian cancer models*
**作者**：Chen, Y., et al.
**摘要**：研究利用Lefty2中和抗体探究其在卵巢癌中的作用。结果显示，Lefty2抗体可抑制上皮-间质转化(EMT)过程，降低肿瘤侵袭性，并延缓小鼠模型中肿瘤生长。抗体通过阻断Lefty2与受体相互作用，逆转促癌信号通路活性。
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**备注**：若需获取全文或更多文献，建议通过PubMed或Web of Science以关键词“Lefty2 antibody”或“Lefty2 function”进一步检索。部分研究可能以“Lefty”或“Lefty-A/B”为标题，需结合具体实验背景筛选。
Lefty2. a member of the TGF-β superfamily, is a secreted signaling protein critical in embryonic development, particularly in establishing left-right asymmetry and regulating cell differentiation. It acts as an antagonist to Nodal signaling, a pathway essential for patterning tissues and organs during embryogenesis. By binding to Nodal or its receptors, Lefty2 modulates the spatial and temporal activity of this pathway, ensuring proper organ positioning and tissue morphogenesis. Dysregulation of Lefty2 has been implicated in developmental disorders and certain cancers, highlighting its biological significance.
Lefty2 antibodies are immunological tools designed to detect, quantify, or inhibit Lefty2 protein in experimental settings. These antibodies are widely used in developmental biology, cancer research, and stem cell studies to investigate Lefty2's role in cellular processes, disease mechanisms, or regenerative medicine. Applications include Western blotting, immunohistochemistry, immunofluorescence, and functional blocking assays. Polyclonal antibodies offer broad epitope recognition, while monoclonal variants provide specificity for particular protein domains. Validation often involves knockout controls or recombinant protein specificity tests. Recent studies also explore Lefty2's potential as a biomarker or therapeutic target, particularly in contexts involving asymmetric signaling or TGF-β pathway dysregulation.
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