Rabbit Polyclonal MouseMed12 Antibody

The Mediator complex subunit 12 (Med12) is a critical component of the multi-protein Mediator complex, which plays an essential role in regulating RNA polymerase II-mediated transcription. Med12. along with Med13. Cdk8. and Cdk19. forms the kinase module of the Mediator complex, involved in modulating transcriptional activation and repression. It acts as a molecular bridge, facilitating communication between transcription factors and the basal transcriptional machinery. Mouse Med12 antibodies are specifically designed to detect the Med12 protein in murine models, enabling researchers to study its expression, localization, and interactions in various biological contexts. These antibodies are widely used in techniques such as Western blotting, immunoprecipitation, immunofluorescence, and chromatin immunoprecipitation (ChIP). Med12 has been implicated in developmental processes, cell differentiation, and signaling pathways, including Wnt/β-catenin and Sonic hedgehog (Shh). Dysregulation of Med12 is associated with diseases such as cancer and developmental disorders. Mouse-specific antibodies are vital for investigating Med12's role in genetically engineered mouse models, offering insights into its physiological and pathological functions. Validated antibodies ensure specificity, often confirmed through knockout (KO) controls, making them indispensable tools in molecular and cellular biology research.