Rabbit Polyclonal RICTOR Antibody

The RICTOR (rapamycin-insensitive companion of mTOR) antibody is a crucial tool in studying the mechanistic target of rapamycin complex 2 (mTORC2), a key signaling complex regulating cell survival, metabolism, and cytoskeletal organization. RICTOR serves as a defining subunit of mTORC2. distinguishing it from mTORC1. Researchers use RICTOR antibodies to investigate the complex's structure, function, and interactions in pathways like PI3K/AKT, which are implicated in cancer, diabetes, and aging. These antibodies enable detection of RICTOR expression levels via techniques such as Western blotting, immunohistochemistry, and immunofluorescence, aiding in exploring mTORC2's role in diseases. Dysregulation of RICTOR/mTORC2 is linked to tumor progression, insulin resistance, and immune disorders, making it a therapeutic target. The antibody's specificity helps distinguish mTORC2 activity from mTORC1. particularly in studies assessing rapamycin sensitivity. Recent studies also highlight RICTOR's involvement in DNA repair and stem cell maintenance. Validated RICTOR antibodies are essential for reproducible research, with commercial clones varying in host species, clonality, and epitope recognition. Ongoing research focuses on mTORC2 inhibition strategies, underscoring the antibody's importance in preclinical drug development and molecular diagnostics.