Rabbit Polyclonal DBP Antibody

The vitamin D-binding protein (DBP), also known as Gc-globulin, is a multifunctional glycoprotein synthesized primarily in the liver. It plays a central role in transporting vitamin D metabolites, including 25-hydroxyvitamin D (25(OH)D) and 1.25-dihydroxyvitamin D (1.25(OH)₂D), through the bloodstream. Beyond transport, DBP participates in immune modulation, actin scavenging during tissue injury, and fatty acid metabolism. Antibodies targeting DBP (anti-DBP) are primarily studied in autoimmune and inflammatory conditions. For instance, anti-DBP autoantibodies have been detected in systemic lupus erythematosus (SLE), where they may interfere with vitamin D bioavailability, potentially contributing to disease progression or bone metabolism abnormalities. Additionally, DBP's genetic polymorphisms (e.g., Gc1s, Gc1f, Gc2) influence its structure and function, which may affect antibody recognition in certain populations. Research also explores anti-DBP antibodies as diagnostic tools or therapeutic targets, particularly in conditions linked to vitamin D dysregulation or chronic inflammation. However, their clinical significance remains under investigation, with studies focusing on their role in modulating immune responses and vitamin D homeostasis.