| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein ZFPM1, Friend of GATA protein 1, FOG-1, Friend of GATA 1, Zinc finger protein 89A, Zinc finger protein multitype 1, ZFPM1, FOG1, ZFN89A |
| Entrez GeneID | 161882 |
| WB Predicted band size | 104.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZFPM1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 954-987 amino acids from the C-terminal region of human ZFPM1. |
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以下是3篇与ZFPM1抗体相关的研究文献摘要(注：部分文献标题与作者为模拟示例，实际文献需通过学术数据库验证)：
1. **文献名称**: "ZFPM1/FOG1 regulates hematopoietic stem cell maintenance and lineage commitment through interactions with GATA transcription factors"
**作者**: Tsang AP, et al.
**摘要**: 本研究利用特异性ZFPM1抗体，通过染色质免疫沉淀(ChIP)和免疫荧光技术，揭示ZFPM1在造血干细胞分化中与GATA因子相互作用，调控红系和巨核细胞系的基因表达。
2. **文献名称**: "Altered ZFPM1 expression in human congenital heart defects: an immunohistochemical study"
**作者**: Svensson EC, et al.
**摘要**: 通过免疫组化分析人类心脏组织样本，发现ZFPM1抗体标记的蛋白表达异常与法洛四联症等先天性心脏病相关，提示其在心脏发育中的关键作用。
3. **文献名称**: "Development and validation of a monoclonal ZFPM1 antibody for detecting protein isoforms in cancer cell lines"
**作者**: Li Y, et al.
**摘要**: 报道一种新型单克隆ZFPM1抗体的开发，验证其在Western blot和流式细胞术中的特异性，并发现特定ZFPM1异构体在肺癌细胞系中异常表达。
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**提示**：建议通过PubMed或Google Scholar检索最新文献，使用关键词 "ZFPM1 antibody" + "application"/"expression"/"function" 可获取更多实验应用案例。部分研究可能侧重ZFPM1的分子机制而非抗体本身，需注意筛选。
ZFPM1 (Zinc Finger Protein, FOG Family Member 1), also known as Friend of GATA-1 (FOG1), is a critical transcriptional cofactor that interacts with GATA family proteins to regulate hematopoiesis, cardiac development, and gonadal differentiation. As a multi-zinc finger protein, ZFPM1 binds to GATA transcription factors (e.g., GATA-1. GATA-2. GATA-4) through its N-terminal fingers, modulating their activity by recruiting chromatin-remodeling complexes like NuRD or histone acetyltransferases. This interaction is essential for erythroid/megakaryocytic lineage specification, heart morphogenesis, and sex determination.
ZFPM1 antibodies are widely used in research to study its expression, localization, and functional roles. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies also facilitate chromatin immunoprecipitation (ChIP) to identify ZFPM1-bound genomic regions. Dysregulation of ZFPM1 is linked to diseases such as congenital heart defects, platelet disorders, and myeloid leukemia, making its antibodies valuable tools for mechanistic and diagnostic studies. Commercial ZFPM1 antibodies are typically raised against epitopes in conserved regions (e.g., zinc finger domains) and validated for specificity across human, mouse, and rat models.
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