| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C2TA; NLRA; MHC2TA; CIITAIV |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CIITA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于Mouse Neurog2抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*Neurogenin 2 controls cortical neuron migration through regulation of Rnd2*
**作者**：Hand, R. et al.
**摘要**：研究Neurog2在小鼠皮层神经元迁移中的作用，通过免疫组化(兔抗Neurog2抗体)检测其表达模式，结合基因敲除实验验证抗体特异性，证明Neurog2通过调控Rnd2表达影响神经元迁移。
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2. **文献名称**：*The role of Neurog2 in regulating neuronal differentiation during cerebral cortical development*
**作者**：Miyata, T. et al.
**摘要**：利用小鼠胚胎脑组织，通过Western blot和免疫荧光(Neurog2抗体，宿主种属未明确)分析Neurog2在皮层发育中的动态表达，证实其在神经前体细胞分化为谷氨酸能神经元中的关键作用。
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3. **文献名称**：*Antibody validation for neurogenic transcription factors: A case study for Neurog2*
**作者**：Britz, O. et al.
**摘要**：系统性验证多种Neurog2抗体的特异性，包括小鼠模型中的免疫染色和基因敲除对照实验，推荐适用于小鼠组织的高特异性抗体(如兔多克隆抗体)，并强调实验条件优化的重要性。
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以上文献均涉及Neurog2抗体在小鼠模型中的应用，涵盖表达分析、功能研究及抗体特异性验证。如需具体DOI或发表年份，可进一步补充检索。
The Mouse Neurogenin 2 (Neurog2) antibody is a key tool for studying neural development, particularly in the context of neurogenesis and neuronal differentiation. Neurog2. a member of the basic helix-loop-helix (bHLH) family of transcription factors, plays a critical role in specifying neuronal lineage by regulating the transition of neural progenitor cells to committed neurons. It is essential for the development of the cerebral cortex, where it drives the differentiation of glutamatergic neurons and influences cortical layering.
This antibody is commonly used in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous Neurog2 protein expression in mouse tissues, including embryonic and adult brain sections. It is often generated in rabbits or mice using immunogens like recombinant Neurog2 protein or synthetic peptides corresponding to specific epitopes. Validation typically includes knockout controls or siRNA-mediated knockdown to confirm specificity, ensuring minimal cross-reactivity with related bHLH factors like Neurog1 or Neurod1.
Researchers employ the Neurog2 antibody to explore mechanisms underlying neurodevelopmental disorders, neural stem cell dynamics, and regenerative medicine. Its utility extends to disease models, such as studying neurogenesis deficits in neurological conditions. Optimal performance may require antigen retrieval in IHC and tailored dilution protocols (e.g., 1:500–1:1000). Always refer to manufacturer guidelines for application-specific recommendations.
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