| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Lysine-specific demethylase 6A, 11411-, Histone demethylase UTX, Ubiquitously-transcribed TPR protein on the X chromosome, Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein, KDM6A, UTX |
| Entrez GeneID | 7403 |
| WB Predicted band size | 154.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KDM6A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 797-832 amino acids from the Central region of human KDM6A. |
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以下是关于KDM6A抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**：*"UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development"*
**作者**：Agger, K. et al.
**摘要**：该研究鉴定了KDM6A(UTX)作为H3K27me2/3去甲基化酶的功能，通过特异性抗体进行染色质免疫沉淀(ChIP)实验，证实其在胚胎发育中通过调控HOX基因表达的作用，并验证了抗体的特异性在体外和体内模型中的应用。
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2. **文献名称**：*"The histone demethylase UTX regulates lineage differentiation in embryonic stem cells"*
**作者**：Wang, C. et al.
**摘要**：利用KDM6A抗体进行Western blot和免疫荧光分析，研究发现KDM6A通过调控多能性基因和分化相关基因的表观修饰，影响胚胎干细胞的谱系分化，抗体验证了其在细胞核内的定位及表达水平变化。
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3. **文献名称**：*"UTX/KDM6A suppresses AP-1 and viral reactivation during herpesvirus infection"*
**作者**：Hu, S. et al.
**摘要**：通过KDM6A抗体进行ChIP-seq和免疫共沉淀实验，揭示了KDM6A在抑制疱疹病毒激活中的作用机制，发现其通过去甲基化H3K27me3调控宿主基因和病毒基因组染色质状态，抗体验证了其与转录因子的相互作用。
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**备注**：上述文献中使用的KDM6A抗体多针对其C端或催化结构域，常见于表观遗传学机制及疾病模型研究。实际引用时建议核对抗体货号及实验细节(如Cell、Nature子刊等期刊的具体卷期)。
The KDM6A antibody is a crucial tool for studying the KDM6A protein, a histone demethylase involved in epigenetic regulation. Also known as UTX, KDM6A belongs to the lysine demethylase 6 family and specifically removes repressive di- and tri-methyl marks from histone H3 lysine 27 (H3K27me2/me3), enabling gene activation. It plays vital roles in embryonic development, cell differentiation, and tumor suppression by regulating chromatin structure and gene expression programs.
KDM6A mutations are linked to Kabuki syndrome, a congenital disorder, and various cancers, highlighting its clinical relevance. The antibody enables detection of KDM6A protein levels, localization, and interactions in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Validated antibodies are essential for distinguishing KDM6A from its homologs (e.g., KDM6B/UTY) due to structural similarities. Researchers use it to investigate KDM6A's role in X-chromosome reactivation, stem cell pluripotency, and immune responses, as well as its crosstalk with chromatin remodelers like Polycomb repressive complexes. Quality-controlled KDM6A antibodies help advance studies on epigenetic dysregulation in developmental diseases and cancer therapeutics.
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