Rabbit Polyclonal (DANRE)gabarapl2(N-term) Antibody

The DANRE Gabarapl2 (N-term) antibody is a specialized tool designed to detect the N-terminal region of Gabarapl2 (Gamma-aminobutyric acid receptor-associated protein-like 2) in the zebrafish model organism *Danio rerio* (DANRE). Gabarapl2. a member of the ATG8 protein family, plays a critical role in autophagy, a cellular degradation process essential for maintaining homeostasis. It shares structural and functional similarities with mammalian GABARAPL2. participating in autophagosome formation, cargo recognition, and vesicle trafficking. This antibody is typically raised in hosts like rabbits or mice using synthetic peptides or recombinant proteins corresponding to the N-terminal epitope of zebrafish Gabarapl2. Its specificity for the N-terminal region ensures targeted recognition, minimizing cross-reactivity with related family members (e.g., Gabarap, LC3). Researchers employ this antibody in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study Gabarapl2 expression, localization, and autophagy dynamics in zebrafish tissues or embryos. Its application is particularly valuable in developmental biology and disease models, where autophagy dysregulation is linked to pathologies like neurodegeneration or cancer. Validation often includes knockout controls or siRNA-mediated knockdown to confirm signal specificity. By enabling precise tracking of Gabarapl2. this antibody supports investigations into autophagy mechanisms and their implications in zebrafish physiology and human diseases.