| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nuclear receptor subfamily 5 group A member 2, Liver receptor homolog 1, LRH-1, Nr5a2, Lrh1 |
| Entrez GeneID | 26424 |
| WB Predicted band size | 64.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Nr5a2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 200-233 amino acids from the Central region of Mouse Nr5a2. |
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以下是关于小鼠Nr5a2抗体的3篇参考文献的简要概括(注：文献信息为虚构示例，实际文献需通过学术数据库查询)：
1. **文献名称**：*"Characterization of Nr5a2 in murine embryonic stem cell pluripotency"*
**作者**：Zhang Y, et al.
**摘要**：研究利用小鼠Nr5a2特异性抗体，通过ChIP-seq和免疫荧光技术，揭示Nr5a2在维持胚胎干细胞多能性中的关键作用，证明其通过调控Oct4和Nanog基因表达影响干细胞自我更新。
2. **文献名称**：*"Nr5a2 antibody-based profiling in pancreatic cancer models"*
**作者**：Smith J, et al.
**摘要**：通过Western blot和免疫组化分析，发现Nr5a2蛋白在胰腺癌小鼠模型中异常高表达。研究使用商业化小鼠Nr5a2抗体，证实其与肿瘤进展和化疗耐药性相关。
3. **文献名称**：*"Generation and validation of a novel monoclonal antibody for murine Nr5a2"*
**作者**：Lee S, et al.
**摘要**：报道一种新型小鼠Nr5a2单克隆抗体的开发，经ELISA、免疫沉淀和免疫染色验证其特异性，成功应用于肝再生研究中Nr5a2蛋白的动态表达检测。
如需具体文献，建议通过PubMed或Web of Science检索关键词“Nr5a2 antibody mouse”或“LRH-1 antibody murine”获取最新研究。
The Mouse Nr5a2 antibody is a tool designed to detect and study the nuclear receptor subfamily 5 group A member 2 (Nr5a2), also known as liver receptor homolog-1 (LRH-1) or fetoprotein transcription factor (FTF). Nr5a2 is a transcription factor belonging to the nuclear receptor superfamily, playing critical roles in embryonic development, stem cell pluripotency, metabolism regulation, and tissue homeostasis. It binds to DNA as a monomer or homodimer, regulating genes involved in cholesterol/bile acid synthesis, pancreatic acinar function, and intestinal crypt cell proliferation. In mice, Nr5a2 is essential for early embryogenesis and organogenesis, particularly in the liver, pancreas, and gastrointestinal tract.
Mouse-specific Nr5a2 antibodies are typically raised in hosts like rabbits or goats using immunogenic peptides or recombinant protein fragments from the mouse Nr5a2 sequence. These antibodies enable researchers to study Nr5a2's expression, localization, and function in murine models through techniques like Western blotting, immunohistochemistry, immunofluorescence, or chromatin immunoprecipitation (ChIP). Validated antibodies show specificity for mouse Nr5a2. often confirmed by knockout controls or siRNA knockdown. Applications include investigating Nr5a2's role in metabolic diseases, cancer progression (e.g., pancreatic or colorectal), and regenerative processes. Their development has advanced mechanistic studies of Nr5a2 in maintaining stemness and mediating nuclear signaling pathways.
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