Rabbit Polyclonal (DANRE)cisd2 Antibody

The CISD2 antibody targets the protein encoded by the *CISD2* gene (CDGSH iron-sulfur domain-containing protein 2), a key regulator of mitochondrial function and cellular longevity. CISD2 is localized to the mitochondrial outer membrane and endoplasmic reticulum, where it modulates calcium homeostasis, redox balance, and autophagy. It plays a critical role in maintaining mitochondrial integrity, influencing energy metabolism, and delaying age-associated pathologies. Studies link *CISD2* dysfunction to Wolfram syndrome type 2 (characterized by diabetes, optic atrophy, and neurodegeneration) and age-related metabolic disorders. The CISD2 antibody is widely used in research to investigate its expression patterns, subcellular localization, and mechanistic roles in diseases. It aids in detecting CISD2 via techniques like Western blot, immunohistochemistry, and immunofluorescence. Recent research highlights CISD2's potential as a therapeutic target for extending healthspan, given its involvement in mitigating oxidative stress and mitochondrial decay. However, challenges remain in fully elucidating its interactome and tissue-specific functions. Commercial CISD2 antibodies are typically validated for specificity using knockout controls, ensuring reliability in experimental models ranging from cell cultures to animal tissues.