Rabbit Polyclonal CNR2(N-term) Antibody

The CNR2 (N-term) antibody is designed to specifically target the N-terminal region of the Cannabinoid Receptor 2 (CNR2), also known as CB2. a G-protein-coupled receptor (GPCR) primarily expressed in immune cells and peripheral tissues. CNR2 plays a key role in modulating immune responses, inflammation, and pain signaling, distinguishing it from the centrally predominant CB1 receptor. The N-terminal domain of CNR2 is critical for receptor trafficking, ligand binding, and interaction with intracellular signaling partners. Antibodies against this region are widely used to study CNR2 expression, localization, and function in physiological and pathological contexts, such as neuroinflammatory disorders, autoimmune diseases, and cancer. Validated in applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), the CNR2 (N-term) antibody helps researchers detect full-length or truncated receptor variants, depending on epitope accessibility. Its specificity is often confirmed using CNR2 knockout controls or peptide-blocking assays. Commercial versions may vary in host species (e.g., rabbit, mouse) and clonality (monoclonal/polyoclonal), with optimized formulations for different sample types (e.g., frozen tissues, cell lysates). Proper validation ensures reliable detection, particularly given CNR2's low expression levels in certain tissues and potential cross-reactivity concerns with related GPCRs.