Rabbit Polyclonal HTR1F Antibody

The HTR1F antibody targets the 5-hydroxytryptamine (serotonin) receptor 1F (HTR1F or 5-HT1F), a G protein-coupled receptor primarily involved in modulating neurotransmitter release and neural signaling. HTR1F is expressed in the central and peripheral nervous systems, particularly in regions like the cerebral cortex, hippocampus, and trigeminal ganglia. It plays a role in pain regulation, migraine pathophysiology, and mood disorders, making it a focus in neuropharmacology research. Antibodies against HTR1F are critical tools for studying receptor localization, expression patterns, and functional interactions in disease models. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate HTR1F's role in migraine mechanisms, neuroinflammation, and psychiatric conditions. Recent studies highlight HTR1F's potential as a therapeutic target, particularly for migraine treatments like lasmiditan, a selective 5-HT1F agonist. Validating HTR1F antibodies requires specificity testing via knockout controls or competitive assays to avoid cross-reactivity with related subtypes (e.g., 5-HT1B/D). Commercial HTR1F antibodies are typically produced in rabbit or mouse hosts, often using synthetic peptides or recombinant protein fragments as immunogens. Researchers should prioritize antibodies with verified applications in their experimental systems to ensure reproducibility, especially given the receptor's low abundance in certain tissues.