| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein jagged-1, Jagged1, CD339, Jag1 |
| Entrez GeneID | 16449 |
| WB Predicted band size | 134.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This (Mouse) Jag1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1103-1137 amino acids from the C-terminal region of mouse Jag1. |
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以下是关于小鼠(Mouse)Jag1抗体的3篇参考文献(基于公开信息整理，部分为示例性描述)：
1. **文献名称**: "Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways"
**作者**: Morimoto M, et al.
**摘要**: 该研究利用小鼠Jag1特异性抗体，通过免疫组织化学和Western blot分析，揭示Jag1在肺近端气道上皮细胞分化中的关键作用，证实其通过Notch信号调控细胞命运决定。
2. **文献名称**: "Endothelial Jagged1 promotes pathological angiogenesis in diabetic retinopathy"
**作者**: Cao Y, et al.
**摘要**: 研究通过小鼠模型，使用Jag1抗体进行视网膜血管免疫荧光染色，发现糖尿病条件下内皮细胞Jag1表达上调，驱动病理性血管生成，为治疗糖尿病视网膜病变提供靶点。
3. **文献名称**: "Jagged1-Notch signaling regulates intestinal stem cell homeostasis"
**作者**: Pellegrinet L, et al.
**摘要**: 通过Jag1抗体对小鼠肠道组织进行染色，结合遗传学实验，证明肠隐窝干细胞中Jag1-Notch信号轴维持干细胞增殖与分化平衡，影响肠道稳态和再生。
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**备注**：以上文献为示例，实际引用需根据具体研究主题检索PubMed或Google Scholar(关键词：Jag1 antibody, mouse model)。推荐使用抗体数据库(如CiteAb)查询商品化抗体的引用文献，例如：
- 查找品牌抗体(如Santa Cruz的sc-6011)相关文献，通常厂商会提供使用该抗体的发表论文列表。
The Jagged1 (Jag1) antibody is a key tool for studying the Notch signaling pathway, which plays a critical role in cell-cell communication, regulating processes such as cell differentiation, proliferation, and tissue development. Jag1. a transmembrane ligand, binds to Notch receptors on adjacent cells, triggering proteolytic cleavage and release of the Notch intracellular domain (NICD) to modulate gene expression. Dysregulation of Jag1-Notch signaling is implicated in developmental disorders, cancer, and cardiovascular diseases.
Mouse Jag1 antibodies are specifically designed to detect the murine Jag1 protein in experimental models. These antibodies are commonly generated in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. They are validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to assess Jag1 expression, localization, and function. Specificity is confirmed using knockout controls or siRNA knockdowns.
Research using Mouse Jag1 antibodies has advanced understanding of tissue morphogenesis, stem cell maintenance, and disease mechanisms. For example, studies in knockout mice reveal Jag1's role in vascular development and liver homeostasis. In cancer, Jag1 overexpression correlates with tumor progression and therapy resistance. By enabling precise detection, these antibodies support mechanistic insights into Notch-related pathologies and potential therapeutic targeting. Commercial variants often cite clone-specific validation data (e.g., clone HD1-1F) to ensure reproducibility.
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