| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor GATA-6, GATA-binding factor 6, GATA6 |
| Entrez GeneID | 2627 |
| WB Predicted band size | 60.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This GATA6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 551-585 amino acids from the C-terminal region of human GATA6. |
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以下是关于GATA6抗体的参考文献示例(内容为虚构，仅供格式参考)：
1. **文献名称**：*GATA6 Expression in Pancreatic Development and Tumorigenesis*
**作者**：Smith J, et al.
**摘要**：研究利用GATA6抗体通过免疫组化分析其在胚胎胰腺发育和胰腺癌中的表达差异，揭示GATA6在维持细胞分化和肿瘤抑制中的双重作用。
2. **文献名称**：*Role of GATA6 in Cardiac Progenitor Cell Differentiation*
**作者**：Lee H, et al.
**摘要**：通过Western blot和免疫荧光技术，证明GATA6抗体在小鼠心脏发育模型中特异性标记前体细胞，调控心肌细胞分化的分子机制。
3. **文献名称**：*GATA6 as a Biomarker in Colorectal Cancer*
**作者**：Garcia R, et al.
**摘要**：基于GATA6抗体的组织微阵列分析，发现GATA6高表达与结直肠癌患者预后不良相关，提示其作为潜在治疗靶点。
4. **文献名称**：*GATA6 Regulates Intestinal Stem Cell Homeostasis*
**作者**：Chen L, et al.
**摘要**：利用GATA6抗体进行流式分选，揭示其在肠道干细胞中的动态表达，调控Wnt信号通路维持上皮再生能力。
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**注**：以上为示例性内容，实际文献需通过PubMed、Google Scholar等平台检索关键词“GATA6 antibody”或结合具体研究领域筛选。
The GATA6 antibody is a crucial tool in studying the GATA6 protein, a member of the GATA transcription factor family characterized by zinc finger DNA-binding domains. GATA6 plays a pivotal role in embryonic development, tissue differentiation, and organogenesis, particularly in the cardiovascular system, pancreas, gastrointestinal tract, and lungs. It regulates gene expression by binding to the consensus DNA sequence (A/T)GATA(A/G), influencing cell proliferation, apoptosis, and lineage specification. Dysregulation of GATA6 is linked to developmental disorders, congenital heart defects, pancreatic dysfunction, and cancers (e.g., gastrointestinal and ovarian tumors).
GATA6 antibodies are widely used in research to detect and quantify protein expression via techniques like immunohistochemistry (IHC), western blotting, and immunofluorescence. They aid in mapping tissue-specific expression patterns, studying developmental pathways, and exploring disease mechanisms. Commercial GATA6 antibodies are typically raised in rabbits or mice against specific epitopes of the human GATA6 protein, with validation in knockout models to ensure specificity. Challenges include cross-reactivity with homologous family members (e.g., GATA4) and variability in performance across experimental conditions. Recent studies also highlight its role in cellular reprogramming and regenerative medicine. As a biomarker, GATA6 expression levels help stratify cancer subtypes and predict therapeutic responses, underscoring its translational relevance.
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