Rabbit Polyclonal RIOK3 Antibody

The RIOK3 antibody is a research tool designed to detect and study the RIO kinase 3 protein, a member of the atypical kinase family. RIOK3 (right-open reading frame kinase 3) is involved in diverse cellular processes, including ribosome biogenesis, cell cycle regulation, and innate immune signaling. Unlike conventional kinases, RIOK3 lacks a canonical ATP-binding motif but retains catalytic activity, contributing to its role in pathways such as NF-κB activation and antiviral responses. Research has linked RIOK3 to cancer progression, viral infections (e.g., HIV, influenza), and inflammatory diseases due to its interaction with signaling molecules like TBK1 and TRAF2. Antibodies targeting RIOK3 enable its detection in techniques like Western blotting, immunofluorescence, and flow cytometry, aiding investigations into its expression patterns, subcellular localization, and functional mechanisms. These antibodies are critical for elucidating RIOK3's dual roles in promoting tumorigenesis (e.g., via TGF-β signaling) and modulating immune responses, making them valuable in both basic research and therapeutic target validation. Specificity and validation (e.g., knockout controls) are essential due to structural similarities among RIO kinase family members.