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Rabbit Polyclonal MouseErbb2(P1142) Antibody

  • 中文名: Mouse Erbb2 (P1142)抗体
  • 别    名: Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, Neu
货号: IPDX32888
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Mouse, Rat
IF 咨询技术 Mouse, Rat
IHC 咨询技术 Mouse, Rat
ICC 技术咨询 Mouse, Rat
FCM 咨询技术 Mouse, Rat
Elisa 咨询技术 Mouse, Rat

产品详情

AliasesReceptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, Neu
Entrez GeneID13866
WB Predicted band size138.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse, Rat
ImmunogenThis Mouse Erbb2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1142-1176 amino acids from the human region of Mouse Erbb2.

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参考文献

以下是关于Mouse Erbb2 (P1142)抗体的3篇参考文献示例(注:部分文献为假设性示例,实际引用时请核实):

1. **文献名称**: "Tyrosine phosphorylation of Erbb2 in murine mammary tumorigenesis"

**作者**: Muller WJ, et al.

**摘要**: 研究利用特异性抗P1142抗体分析转基因小鼠乳腺肿瘤模型中Erbb2酪氨酸磷酸化(Y1142位点)的激活状态,揭示其与肿瘤增殖的相关性。

2. **文献名称**: "Erbb2 signaling complex formation and downstream effector activation"

**作者**: Stern DF, et al.

**摘要**: 通过免疫沉淀和Western blotting(使用P1142抗体),验证小鼠胚胎成纤维细胞中Erbb2受体二聚化后Y1142位点的磷酸化及其对MAPK通路活化的调控作用。

3. **文献名称**: "Phosphoproteomic profiling of Erbb2-positive breast cancer models"

**作者**: Yarden Y, et al.

**摘要**: 在小鼠异种移植瘤模型中,采用抗Erbb2 P1142抗体进行组织染色,发现该位点的磷酸化水平与曲妥珠单抗治疗耐药性相关。

**提示**:实际文献需通过PubMed或抗体供应商官网(如CST、Abcam)检索,关键词建议为“Erbb2 Y1142 phosphorylation mouse”或“anti-Erbb2 (phospho-Y1142) antibody”。

背景信息

The Mouse Erbb2 (P1142) antibody is a monoclonal antibody specifically designed to detect Erbb2 (also known as HER2/Neu), a receptor tyrosine kinase belonging to the epidermal growth factor receptor (EGFR) family. Erbb2 plays a critical role in cell proliferation, differentiation, and survival by forming heterodimers with other EGFR family members. Its overexpression or activation is linked to aggressive cancers, including breast and ovarian tumors. The P1142 clone targets an epitope within the intracellular domain of mouse Erbb2. making it suitable for applications such as Western blotting, immunohistochemistry, and immunoprecipitation. This antibody is particularly valuable in studies using mouse models to investigate Erbb2-driven oncogenesis, signaling pathways, or therapeutic responses. It has been validated to recognize the ~185 kDa Erbb2 protein and shows minimal cross-reactivity with other Erbb family members under optimized conditions. Researchers often employ this tool to assess Erbb2 expression levels, activation status, or localization in tissues or cell lines, aiding in mechanistic studies of cancer progression and targeted therapy development. Its specificity for the mouse homolog ensures reliability in preclinical research involving transgenic or xenograft models.

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