| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Chromobox protein homolog 7, Cbx7, D15Ertd417e |
| Entrez GeneID | 52609 |
| WB Predicted band size | 18.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Cbx7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 144-178 amino acids from the C-terminal region of human Mouse Cbx7. |
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以下是3篇与小鼠Cbx7抗体相关的文献摘要信息(基于近年研究领域推测，具体文献年份和作者可能需要结合最新数据库核实)：
1. **文献名称**: *Cbx7 is required for hematopoietic stem cell maintenance through regulation of the cell cycle*
**作者**: Klauke K, et al.
**摘要**: 该研究利用Cbx7特异性抗体(通过ChIP和免疫荧光验证)，证明Cbx7通过调控细胞周期相关基因(如p16Ink4a)维持造血干细胞静息状态，缺失Cbx7会导致干细胞耗竭和衰老表型。
2. **文献名称**: *Polycomb protein Cbx7 regulates cellular senescence and aging in vivo*
**作者**: Ologhlen N, et al.
**摘要**: 通过Cbx7抗体(Western Blot和免疫组化验证)发现，Cbx7通过抑制INK4a/ARF位点延缓细胞衰老，其表达水平随年龄增长下降，提示其在衰老相关疾病中的作用。
3. **文献名称**: *Cbx7 suppresses hepatocellular carcinoma progression through repression of Wnt/β-catenin signaling*
**作者**: Scott CL, et al.
**摘要**: 研究使用Cbx7抗体(已验证特异性)分析肝癌样本，发现Cbx7通过抑制Wnt通路靶基因(如c-Myc)抑制肿瘤生长，其低表达与患者预后不良相关。
4. **文献名称**: *Cbx7 controls pluripotency of germline stem cells by regulating PRC1 complex activity*
**作者**: Bernardo AS, et al.
**摘要**: 利用Cbx7抗体(ChIP-seq验证)揭示其在生殖干细胞中通过调控PRC1复合体活性维持多能性，Cbx7缺失导致分化异常和干细胞标志物丢失。
**注意**：以上文献信息为模拟示例，实际引用需通过PubMed或Web of Science等数据库检索确认具体标题、作者及摘要内容。建议使用关键词“Cbx7 antibody”、“Cbx7 Polycomb”、“Cbx7 knockout”结合抗体品牌(如Abcam、Cell Signaling Technology)进行精准搜索。
The mouse Cbx7 antibody is a crucial tool for studying the role of Chromobox homolog 7 (Cbx7), a member of the Polycomb group (PcG) protein family. Cbx7 is a core component of Polycomb repressive complex 1 (PRC1), which mediates gene silencing through chromatin modification. It recognizes trimethylated histone H3 lysine 27 (H3K27me3), a mark deposited by PRC2. facilitating PRC1 recruitment to maintain transcriptional repression of target genes, particularly those involved in differentiation and development. Cbx7 plays dual roles in cellular processes: it regulates stem cell pluripotency by suppressing differentiation genes and acts contextually as an oncogene or tumor suppressor in cancers. For instance, it is overexpressed in certain malignancies (e.g., prostate cancer) but downregulated in others (e.g., some leukemias).
The antibody enables detection of Cbx7 in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). It is typically raised in rabbits or mice, either as monoclonal or polyclonal forms, and validated using knockout controls to ensure specificity. Researchers utilize this antibody to explore Cbx7’s involvement in epigenetic regulation, cancer progression, and stem cell biology, making it vital for dissecting PRC1-mediated mechanisms in health and disease.
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