| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tyrosine-protein kinase receptor TYRO3, Etk2/tyro3, TK19-2, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase TIF, Tyro3, Dtk, Rse, Tif |
| Entrez GeneID | 22174 |
| WB Predicted band size | 96.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Tyro3 antibody is generated from a mouse immunized with a recombinant protein. |
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以下是关于Tyro3抗体的3篇代表性文献，内容简明概括：
1. **文献名称**: *"TAM receptor signaling in immune homeostasis"*
**作者**: Lemke G.
**摘要**: 该综述探讨了TAM受体(Tyro3、Axl、MerTK)在免疫调节中的作用，重点提到Tyro3抗体在抑制炎症反应和自身免疫疾病模型中的应用，揭示了其通过调控巨噬细胞和树突状细胞功能维持免疫稳态的机制。
2. **文献名称**: *"Targeting Tyro3 in cancer: Rationale and preclinical evidence"*
**作者**: Zhu C. et al.
**摘要**: 研究开发了一种人源化抗Tyro3单克隆抗体，体外实验显示其能有效阻断配体Gas6介导的肿瘤细胞增殖和迁移，并在小鼠模型中抑制了黑色素瘤和乳腺癌的转移，提示其作为靶向治疗的潜力。
3. **文献名称**: *"Tyro3 regulates synaptic plasticity and cognition in the hippocampus"*
**作者**: Prieto GA. et al.
**摘要**: 通过特异性Tyro3抗体阻断实验，发现Tyro3在海马神经元突触可塑性中起关键作用，其信号通路缺陷与阿尔茨海默病模型小鼠的认知衰退相关，提示抗体工具在神经疾病机制研究中的应用价值。
(注：以上文献信息为模拟示例，实际引用需以具体论文为准。)
The Tyro3 protein, a member of the TAM receptor tyrosine kinase family (including Axl and Mer), plays critical roles in cellular signaling pathways regulating immune response, cell survival, proliferation, and phagocytosis. Initially identified in the nervous system, Tyro3 is activated by ligands such as Gas6 and Protein S, which bind to its extracellular domain to trigger downstream signaling. It is widely expressed in neurons, reproductive tissues, and immune cells, and has been implicated in neurodevelopment, spermatogenesis, and immune homeostasis. Dysregulation of Tyro3 is associated with diseases including cancer (e.g., metastasis, drug resistance), autoimmune disorders (e.g., lupus), and neurodegenerative conditions (e.g., Alzheimer’s).
Tyro3 antibodies are essential tools for studying its expression, localization, and function. They enable applications like Western blotting, immunohistochemistry, and flow cytometry to assess protein levels in disease models. Therapeutic Tyro3-targeting antibodies are also under exploration to modulate aberrant signaling in cancers or autoimmune diseases. Challenges remain in specificity due to structural similarities among TAM receptors, driving efforts to develop selective antibodies. Current research focuses on elucidating Tyro3's dual roles in promoting tumor progression versus sustaining neural health, highlighting its potential as a biomarker or therapeutic target in precision medicine.
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