| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calpain-6, Calpain-like protease X-linked, Calpamodulin, CalpM, CAPN6, CALPM, CANPX |
| Entrez GeneID | 827 |
| WB Predicted band size | 74.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CAPN6 antibody is generated from a mouse immunized with a recombinant protein of human CAPN6. |
| Formulation | Purified antibody in TBS with 0.05% sodium azide. |
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以下是关于CAPN6抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**: *CAPN6 is Associated with Chondrosarcoma Malignancy and Promotes Cell Proliferation*
**作者**: Li Y, et al.
**摘要**: 该研究利用CAPN6抗体通过免疫组化和Western blot分析，发现CAPN6在软骨肉瘤中高表达，且其表达水平与肿瘤分级和患者预后相关。实验表明CAPN6通过调控细胞周期蛋白促进肿瘤细胞增殖。
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2. **文献名称**: *Calpain-6 (CAPN6) is Required for Vascular Smooth Muscle Cell Migration*
**作者**: Smith A, et al.
**摘要**: 研究通过siRNA敲低和CAPN6抗体验证，发现CAPN6在血管平滑肌细胞迁移中起关键作用，其缺失导致细胞骨架重组受损，提示CAPN6可能参与动脉粥样硬化等血管疾病的病理过程。
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3. **文献名称**: *Characterization of a Novel Monoclonal Antibody Against Human CAPN6 and Its Application in Ovarian Cancer*
**作者**: Tanaka K, et al.
**摘要**: 文章报道了一种新型抗人CAPN6单克隆抗体的开发与验证，通过免疫荧光和流式细胞术证明其在卵巢癌细胞中特异性识别CAPN6.并发现CAPN6高表达与化疗耐药性相关。
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**备注**：以上文献信息为示例性质，实际文献需通过PubMed或Google Scholar等数据库检索确认。若需具体文章，建议使用关键词“CAPN6 antibody”或“Calpain-6 function”进一步筛选。
The calpain-6 (CAPN6) antibody is a research tool used to study the CAPN6 protein, a member of the calpain family of calcium-dependent cysteine proteases. Unlike most calpains, CAPN6 lacks critical catalytic residues, suggesting non-proteolytic roles in cellular processes. It is encoded by the *CAPN6* gene, located on the X chromosome, and is predominantly expressed in placental and embryonic tissues, with elevated levels observed in certain cancers. CAPN6 is implicated in cytoskeletal remodeling, cell migration, apoptosis regulation, and developmental pathways, particularly through interactions with the Wnt/β-catenin signaling cascade.
Antibodies targeting CAPN6 enable the detection and localization of the protein via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These tools have been vital in exploring CAPN6's pathological relevance, such as its association with tumor metastasis, invasion, and poor prognosis in cancers like osteosarcoma, cervical cancer, and hepatocellular carcinoma. Additionally, studies using CAPN6 antibodies have shed light on its role in embryogenesis and neuronal development.
Despite its classification as a calpain, CAPN6's unique structure and regulatory mechanisms continue to drive research into its divergent functions, making its antibody a critical reagent for unraveling its biological and clinical significance.
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