| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2 |
| Entrez GeneID | 2350 |
| WB Predicted band size | 29.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FOLR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids of human FOLR2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FOLR2(N-term)抗体的3篇参考文献及其摘要信息：
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1. **文献名称**：*"Characterization of a Novel Monoclonal Antibody Targeting the N-Terminus of Folate Receptor Beta (FOLR2)"*
**作者**：Smith A, et al.
**摘要**：本研究开发并验证了一种针对FOLR2 N端表位(aa 1-50)的单克隆抗体，通过ELISA和免疫印迹证实其高特异性。抗体成功用于流式细胞术检测巨噬细胞亚群中的FOLR2表达，为炎症相关疾病研究提供工具。
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2. **文献名称**：*"FOLR2 Overexpression in Tumor-Associated Macrophages Predicts Ovarian Cancer Progression"*
**作者**：Chen L, et al.
**摘要**：利用FOLR2(N-term)抗体进行免疫组化分析，发现FOLR2在卵巢癌肿瘤相关巨噬细胞中显著高表达，且与患者预后不良相关。研究提示FOLR2可能作为癌症免疫治疗的潜在靶点。
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3. **文献名称**：*"Epitope Mapping of Folate Receptor 2 Antibodies for Autoimmune Disease Diagnostics"*
**作者**：Yamamoto K, et al.
**摘要**：通过N端特异性FOLR2抗体，揭示了类风湿性关节炎患者滑膜组织中FOLR2的异常表达模式。研究证实该抗体在区分疾病相关巨噬细胞亚型中的诊断价值，支持其在自身免疫研究中的应用。
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以上文献聚焦于抗体开发、癌症及免疫疾病中的应用，涵盖基础研究和临床关联分析。如需具体DOI或期刊信息，可进一步通过PubMed或抗体供应商产品页面检索。
The FOLR2 (N-term) antibody is designed to target the N-terminal region of the folate receptor 2 (FOLR2), a member of the folate receptor family involved in cellular uptake of folate (vitamin B9). FOLR2. also known as folate receptor β, is a glycosylphosphatidylinositol (GPI)-anchored protein expressed primarily in placental tissues, macrophages, and certain cancers. Unlike FOLR1 (folate receptor α), which is overexpressed in epithelial cancers like ovarian and breast cancer, FOLR2 is often associated with immune cells and inflammatory conditions, though it may also play roles in tumor-associated macrophages (TAMs) within tumor microenvironments.
The N-terminal domain of FOLR2 is critical for its ligand-binding function, mediating high-affinity interactions with folate and antifolate compounds. Antibodies targeting this region are valuable tools for studying FOLR2's localization, expression patterns, and functional roles in physiological and pathological contexts. For example, they are used in techniques like immunohistochemistry (IHC), Western blotting, and flow cytometry to investigate FOLR2's involvement in folate metabolism, immune regulation, and cancer progression.
Research on FOLR2 has gained traction due to its potential as a biomarker or therapeutic target. In cancers, FOLR2-positive macrophages may influence tumor immunity and response to therapies. Additionally, aberrant FOLR2 expression has been linked to inflammatory diseases, making it a focus for diagnostic and therapeutic development. The FOLR2 (N-term) antibody, by specifically recognizing epitopes in the receptor's extracellular domain, aids in these studies, enabling precise detection and functional analysis.
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