Rabbit Polyclonal PAFAH1B1(N-term) Antibody

The PAFAH1B1 (N-term) antibody is designed to target the N-terminal region of the Platelet-Activating Factor Acetylhydrolase 1B Regulatory Subunit 1 (PAFAH1B1), also known as LIS1. This protein plays a critical role in neuronal migration during brain development by regulating microtubule dynamics and interacting with components of the cytoplasmic dynein complex. Mutations in the PAFAH1B1 gene are linked to Miller-Dieker lissencephaly syndrome, a severe neurodevelopmental disorder characterized by smooth brain surfaces (lissencephaly), intellectual disability, and seizures. The N-terminal region of PAFAH1B1 is essential for its interaction with other proteins, including the catalytic subunits of the PAFAH complex and nuclear distribution protein NUDC. Antibodies specific to this region are widely used in neuroscience and developmental biology research to study PAFAH1B1 expression, localization, and function in cellular models, tissue samples, or disease contexts. They are validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence, aiding in investigations of neurodevelopmental disorders, cancer (where PAFAH1B1 dysregulation is implicated), and mechanisms of intracellular transport. Proper validation, including knockout controls, ensures specificity for accurate experimental outcomes.