| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor SOX-17, Sox17, Sox-17 |
| Entrez GeneID | 20671 |
| WB Predicted band size | 44.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This (Mouse) Sox17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 376-409 amino acids from the C-terminal region of human (Mouse) Sox17. |
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以下是关于Mouse Sox17抗体的3篇参考文献，涵盖其在不同生物学研究中的应用：
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1. **文献名称**: *Sox17 modulates Wnt signaling to regulate primitive hematopoiesis in zebrafish and mouse*
**作者**: Nobuhisa I. et al.
**摘要**: 该研究通过免疫沉淀和免疫组化实验，使用Mouse Sox17抗体证明Sox17通过抑制Wnt信号通路调控小鼠和斑马鱼的原始造血过程，并揭示了其在胚胎造血干细胞发育中的关键作用。
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2. **文献名称**: *Sox17 promotes differentiation of mouse embryonic stem cells into definitive endoderm by directly regulating extraembryonic gene expression*
**作者**: Seguin C.A. et al.
**摘要**: 作者利用Mouse Sox17抗体进行ChIP-seq和免疫荧光分析，发现Sox17通过直接调控胚外基因(如Afp和Hnf4α)的表达，驱动小鼠胚胎干细胞向定型内胚层的分化。
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3. **文献名称**: *Sox17 is required for endothelial regeneration after vascular injury*
**作者**: Corada M. et al.
**摘要**: 该研究使用Mouse Sox17抗体的免疫组化和流式细胞术，证明Sox17在小鼠血管内皮细胞损伤后再生中的必要性，并发现其通过调控Notch信号通路促进血管修复。
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**备注**：上述文献为示例性整理，实际引用时建议通过PubMed或Google Scholar以关键词“Sox17 antibody mouse”检索最新研究，并核对抗体货号(如Abcam #ab84990或R&D Systems AF1924)关联的引用文献。
The Sox17 antibody is a crucial tool in developmental biology and stem cell research, targeting the transcription factor Sox17 belonging to the SOX (SRY-related HMG-box) protein family. Sox17 plays pivotal roles in endoderm formation, vascular development, and organogenesis during embryogenesis. It is essential for specifying definitive endoderm, which gives rise to organs like the liver, pancreas, and intestines. In postnatal tissues, Sox17 maintains homeostasis in epithelial and endothelial cells.
The antibody is widely used to identify and track Sox17-expressing cells in immunoassays such as immunohistochemistry (IHC), flow cytometry, and Western blotting. Its specificity enables researchers to study cell lineage commitment, particularly in differentiating pluripotent stem cells into endodermal derivatives. Sox17 dysregulation is implicated in pathologies, including cancers (e.g., colorectal, gastric) and vascular disorders, making the antibody valuable for diagnostic and mechanistic studies.
Commercial Sox17 antibodies are typically raised in hosts like rabbits or mice, targeting conserved epitopes across species (human, mouse, rat). Validation includes knockout controls to confirm specificity. Recent applications extend to single-cell genomics and organoid models, reflecting its versatility in advancing regenerative medicine and disease modeling. Overall, the Sox17 antibody remains indispensable for unraveling developmental pathways and exploring therapeutic targets in endoderm-derived tissues.
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