| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein delta homolog 1, DLK-1, Adipocyte differentiation inhibitor protein, Preadipocyte factor 1, Pref-1, Fetal antigen 1, FA1, Dlk1, Dlk, Pref1, Scp-1 |
| Entrez GeneID | 13386 |
| WB Predicted band size | 41.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This (Mouse) Dlk1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 372-405 amino acids from the C-terminal region of human (Mouse) Dlk1. |
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以下是关于小鼠(Mouse)Dlk1抗体的3篇参考文献示例，简要概括了研究主题及抗体应用：
1. **文献名称**：*Dlk1 regulates the development of fetal hematopoietic stem cells in mice*
**作者**：Suzuki M, et al.
**摘要**：该研究通过免疫组化和流式细胞术，利用小鼠Dlk1抗体检测了胎肝造血干细胞中Dlk1蛋白的表达，发现Dlk1在早期造血干细胞自我更新中起关键调控作用。
2. **文献名称**：*Dlk1 functions as a regulator of adipogenesis in mouse preadipocytes*
**作者**：Lee Y, et al.
**摘要**：研究通过Western blot和免疫荧光技术，使用特异性Dlk1抗体验证其在脂肪前体细胞分化中的动态表达，表明Dlk1通过抑制PPARγ信号通路调控脂肪生成。
3. **文献名称**：*Dlk1 as a potential therapeutic target in neuroendocrine tumors of mice*
**作者**：Kawai T, et al.
**摘要**：文章利用小鼠Dlk1抗体对神经内分泌肿瘤模型进行组织染色，发现Dlk1高表达与肿瘤侵袭性相关，并通过抗体阻断实验探索其作为治疗靶点的潜力。
**备注**：以上文献为示例，实际引用需根据具体研究检索PubMed或Google Scholar获取完整信息。建议使用关键词“Dlk1 antibody mouse”或“Delta-like 1 homolog (Dlk1) murine studies”进行精确检索。
**Background of DLK1 Antibody**
The **Delta-like 1 homolog (DLK1)**, also known as Pref-1. is a transmembrane protein belonging to the epidermal growth factor (EGF)-like repeat-containing family. It plays critical roles in cellular differentiation, particularly in adipogenesis, where it inhibits adipocyte maturation, and in stem cell regulation. DLK1 is highly expressed during embryonic development, influencing tissue formation in skeletal muscle, adrenal glands, and pancreatic islets, but its expression declines in most adult tissues.
**DLK1 antibodies** are essential tools for detecting and studying this protein in research. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to investigate DLK1's expression patterns and functions. DLK1 exists in membrane-bound and soluble forms (via proteolytic cleavage), and specific antibodies may target different isoforms or epitopes.
Aberrant DLK1 expression is linked to metabolic disorders (e.g., obesity, diabetes), cancers (e.g., neuroblastoma, hepatocellular carcinoma), and developmental anomalies. For instance, elevated DLK1 levels are associated with tumor progression and poor prognosis in certain malignancies. In metabolic studies, DLK1 antibodies help elucidate its role in adipose tissue expansion and insulin signaling.
When selecting a DLK1 antibody, considerations include its specificity (validated via knockout controls), host species (e.g., rabbit, mouse), and compatibility with intended applications. Researchers also prioritize antibodies recognizing conserved regions to ensure cross-reactivity in multiple model organisms.
Overall, DLK1 antibodies are pivotal in advancing understanding of developmental biology, cancer mechanisms, and metabolic regulation, bridging molecular insights to potential therapeutic targets.
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