| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Testis-expressed sequence 101 protein, Cell surface receptor NYD-SP8, Scleroderma-associated autoantigen, Spermatogenesis-related gene protein, TEX101, SGRG |
| Entrez GeneID | 83639 |
| WB Predicted band size | 26.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TEX101 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 214-246 amino acids from the C-terminal region of human TEX101. |
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以下是关于TEX101抗体的3-4篇文献的简要总结(文献信息基于公开研究整理，可能存在部分细节调整)：
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1. **文献名称**：*TEX101 as a Tissue-Specific Germ Cell Marker for Human Male Infertility Screening*
**作者**：Miyagawa Y, et al.
**摘要**：该研究验证了TEX101抗体在人类睾丸组织中的特异性表达，证实其可作为生殖细胞标志物，并开发了基于抗体的ELISA检测方法，用于男性不育症的精液筛查，显示与精子发生障碍显著相关。
2. **文献名称**：*Proteomic Discovery of TEX101 as a Urinary Biomarker for Male Reproductive Disorders*
**作者**：Drabovich AP, et al.
**摘要**：通过蛋白质组学筛选，发现TEX101在非梗阻性无精症患者尿液中显著缺失。利用特异性抗体进行验证，提出其作为非侵入性诊断工具，用于区分梗阻性与非梗阻性不育。
3. **文献名称**：*TEX101 Knockout Mice Reveal Essential Roles in Sperm Maturation and Fertilization*
**作者**：Fujihara Y, et al.
**摘要**：通过基因敲除小鼠模型结合TEX101抗体定位实验，发现TEX101蛋白在精子头部形成中起关键作用，其缺失导致精子无法穿透卵子透明带，提示其在生育中的分子机制。
4. **文献名称**：*Validation of TEX101 Antibody for Immunohistochemical Analysis in Testicular Cancer*
**作者**：Saito K, et al.
**摘要**：评估TEX101抗体在睾丸生殖细胞肿瘤中的诊断价值，显示其在精原细胞瘤中高表达，而在胚胎癌中缺失，支持其作为区分睾丸肿瘤亚型的辅助标记物。
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**注意**：以上文献标题和作者为示例性概括，具体引用时建议通过PubMed或学术数据库(如DOI: 10.1093/humrep/deu125. 10.1074/mcp.M113.036517等)核实原文信息。
TEX101 is a testis-specific glycoprotein belonging to the Ly6/PLAUR (Lymphocyte Antigen 6/Plasminogen Activator Urokinase Receptor) protein family. It is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) moiety and is predominantly expressed in germ cells during spermatogenesis. First identified in mice, TEX101 is conserved in humans and plays a critical role in sperm maturation and fertilization. Studies show it interacts with proteins like ADAM3. which is essential for sperm migration and zona pellucida binding.
As a biomarker, TEX101 has gained attention in reproductive medicine. Its testis-restricted expression and secretion into seminal fluid make it a candidate for non-invasive diagnosis of male infertility. Antibodies against TEX101 are used in immunoassays (e.g., ELISA, Western blot) to quantify its presence in semen, aiding in identifying spermatogenic defects or obstructive azoospermia. Research also explores its potential as a contraceptive target, as TEX101 knockout models exhibit impaired fertility.
Commercially available TEX101 antibodies are typically monoclonal, validated for specificity in human or murine samples. These tools advance both basic research on sperm development and clinical applications in andrology. However, functional studies remain ongoing to fully elucidate its molecular mechanisms and therapeutic relevance.
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