关键信息
-
基因名
Cltrn
- 应用
-
别名
Transmembrane protein 27
-
种属
Mouse
-
表达系统
E. coli
-
标签
N- His-SUMO & C- Myc
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9ESG4
-
表达区间
15-141aa
-
分子量
34.5 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Cltrn, or Clathrin, is a key protein involved in the endocytic pathway, facilitating the internalization of various molecules and signaling receptors from the cell surface. The study of Cltrn is critical because it plays a vital role in maintaining cellular homeostasis, regulating membrane trafficking, and contributing to processes such as nutrient uptake, synaptic vesicle recycling, and signal transduction. Dysregulation of clathrin-mediated endocytosis has been implicated in a range of diseases, including neurodegenerative disorders, cancer, and metabolic syndromes. Recent advances in molecular biology techniques, such as CRISPR-Cas9 and advanced imaging methods, have enabled researchers to investigate the structure and function of Cltrn with greater precision. Understanding the mechanisms of Cltrn assembly, its interaction with various adaptor proteins, and its role in pathogenic processes is essential for the development of targeted therapies. Ongoing research aims to elucidate how Cltrn dynamics can impact cellular communication and response to environmental stimuli, paving the way for novel therapeutic strategies in treating diseases associated with endocytic dysfunction. Thus, the exploration of Cltrn and its associated pathways remains a significant focus in cellular and molecular biology research, offering insights into both fundamental cellular processes and potential clinical applications.
