Rabbit Polyclonal TRIM60 Antibody

The TRIM60 antibody is a tool used to study TRIM60 (Tripartite Motif-Containing Protein 60), a member of the TRIM family of proteins characterized by conserved RING, B-box, and coiled-coil domains. TRIM60 is implicated in diverse cellular processes, including innate immunity, protein ubiquitination, and antiviral responses. Though its exact biological roles remain less characterized compared to other TRIM proteins, TRIM60 is hypothesized to function as an E3 ubiquitin ligase, modulating protein degradation pathways and immune signaling. Research suggests potential involvement in spermatogenesis, as TRIM60 expression is enriched in the testis, though its regulatory mechanisms and interactions are still under investigation. The TRIM60 antibody enables detection and localization of the protein in experimental models (e.g., Western blot, immunohistochemistry) to explore its expression patterns, post-translational modifications, and disease associations. Current studies focus on its role in cellular stress responses, immune regulation, and possible links to pathological conditions like infections or cancer. However, limited data exist on TRIM60-specific pathways, highlighting the need for further research. Commercial TRIM60 antibodies are typically validated for specificity using knockout controls or siRNA-based approaches, ensuring reliability in both basic and translational studies.