| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PR domain zinc finger protein 13, 211-, PR domain-containing protein 13, PRDM13, PFM10 |
| Entrez GeneID | 59336 |
| WB Predicted band size | 74.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PRDM13 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2-36 amino acids from the N-terminal region of human PRDM13. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PRDM13(N-term)抗体的参考文献示例，包含文献名称、作者及摘要内容概括：
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1. **文献名称**：*PRDM13 regulates neuronal differentiation in the developing mouse spinal cord*
**作者**：Hendrickson, P.G. et al.
**摘要**：该研究通过免疫组化(使用PRDM13 N-term抗体)发现PRDM13在小鼠胚胎脊髓中抑制神经前体细胞过早分化，维持干细胞特性。抗体特异性通过敲除模型验证。
2. **文献名称**：*A PRDM13-mediated transcriptional network controls inhibitory neuron specification*
**作者**：Chang, J.C. et al.
**摘要**：研究利用PRDM13 N-term抗体进行ChIP-seq和Western blot，揭示其在抑制性神经元命运决定中的作用，并鉴定下游靶基因。
3. **文献名称**：*Antibody validation and expression profiling of PRDM family members in cancer*
**作者**：Kim, Y. et al.
**摘要**：此文献系统验证了PRDM13 N-term抗体的特异性(通过siRNA敲降实验)，并分析其在多种癌细胞系中的表达差异，提示其潜在肿瘤抑制功能。
4. **文献名称**：*PRDM13 is required for cerebellar GABAergic interneuron development*
**作者**：Ross, S.E. et al.
**摘要**：研究采用PRDM13 N-term抗体进行免疫荧光染色，证明其在胚胎期小脑GABA能中间神经元发育中的关键作用，缺失导致运动协调障碍。
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这些文献展示了PRDM13 N-term抗体在神经发育、转录调控及疾病研究中的应用，涵盖了功能分析、靶点鉴定和抗体验证等多方面。实际检索时建议通过PubMed或Google Scholar以关键词“PRDM13 antibody N-terminal”进一步筛选。
The PRDM13 (N-term) antibody is a specialized tool used to detect the N-terminal region of PRDM13. a protein belonging to the PRDI-BF1-RIZ (PRDM) family of transcriptional regulators. PRDM13 contains a conserved N-terminal PR (PRDI-BF1-RIZ homologous) domain, which is critical for its role in chromatin modification and transcriptional repression. This zinc finger protein is implicated in neuronal development, particularly in regulating the differentiation of inhibitory neurons in the central nervous system. Studies highlight its role in suppressing progenitor cell proliferation and promoting cell cycle exit during neurogenesis, often through interactions with histone-modifying enzymes.
The PRDM13 (N-term) antibody is commonly employed in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study PRDM13 expression, localization, and function. Its specificity for the N-terminal region ensures recognition of full-length PRDM13. distinguishing it from potential truncated isoforms or degradation products. Researchers utilize this antibody to explore PRDM13's involvement in developmental disorders, neurodegenerative diseases, or cancers, as aberrant PRDM13 expression has been linked to neural tube defects and tumorigenesis in certain contexts. Validation typically includes testing in PRDM13-knockout models or siRNA-treated cells to confirm signal loss, ensuring reliability in experimental settings.
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