Rabbit Polyclonal (DANRE)mab21l2 Antibody

The DANRE (Danio rerio) mab21l2 antibody is a tool used to study the Mab-21 domain-containing protein 2 (Mab21l2) in zebrafish, a model organism for developmental biology. Mab21l2 belongs to the evolutionarily conserved mab-21 gene family, implicated in cell fate determination, organogenesis, and neural development. In zebrafish, mab21l2 plays critical roles in eye development, neural tube patterning, and limb formation, with mutations linked to developmental defects such as microphthalmia and impaired neurogenesis. The antibody is typically generated against specific epitopes of the zebrafish Mab21l2 protein, enabling detection via techniques like immunohistochemistry, Western blotting, or immunofluorescence. Its applications include mapping expression patterns during embryogenesis, analyzing loss-of-function phenotypes in mutant strains, and investigating interactions with signaling pathways like TGF-β/BMP. Researchers utilize this antibody to explore conserved developmental mechanisms and model human congenital disorders affecting sensory organs or the nervous system. Validation often involves knockout controls or cross-reactivity tests with homologous proteins. As zebrafish studies increasingly bridge developmental biology and disease research, the mab21l2 antibody remains vital for dissecting molecular mechanisms underlying tissue morphogenesis and genetic pathologies.