| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitochondrial import receptor subunit TOM40B, Protein TOMM40-like, TOMM40L, TOMM40B |
| Entrez GeneID | 84134 |
| WB Predicted band size | 33.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This TOMM40L antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 25-58 amino acids from the N-terminal region of human TOMM40L. |
+ +
以下是关于 **TOMM40L (N-term) 抗体** 的模拟参考文献示例(实际文献可能需要通过学术数据库查询)：
---
1. **文献名称**：*Characterization of TOMM40L Antibody for Mitochondrial Membrane Protein Studies*
**作者**：Smith A, et al.
**摘要**：该研究开发了一种针对 TOMM40L N 端结构域的多克隆抗体，验证了其在人细胞系中线粒体外膜的免疫荧光定位能力，并用于探究 TOMM40L 与阿尔茨海默病相关蛋白 APOE 的潜在相互作用。
2. **文献名称**：*TOMM40L Expression and Its Role in Cellular Aging*
**作者**：Chen B, et al.
**摘要**：通过 Western blot 和免疫组化技术，使用 TOMM40L (N-term) 抗体发现该蛋白在衰老细胞中线粒体膜的表达显著下调，提示其可能参与线粒体功能障碍相关的衰老过程。
3. **文献名称**：*Development of a Novel Monoclonal Antibody Targeting the N-terminal Domain of TOMM40L*
**作者**：Kimura T, et al.
**摘要**：研究报道了一种高特异性抗 TOMM40L N 端的单克隆抗体的制备，验证了其在多种组织样本中的适用性，并用于研究 TOMM40L 在神经退行性疾病模型中的表达变化。
4. **文献名称**：*TOMM40L as a Potential Biomarker in Alzheimer's Disease: Insights from Antibody-based Assays*
**作者**：Johnson R, et al.
**摘要**：利用 TOMM40L (N-term) 抗体进行脑脊液样本分析，发现 TOMM40L 表达水平与阿尔茨海默病早期病理标志物(如 Aβ 和 tau)存在相关性，提示其作为生物标志物的潜力。
---
**备注**：以上为模拟示例，实际文献需通过 **PubMed** 或 **Google Scholar** 等平台检索关键词“TOMM40L antibody N-terminal”或“TOMM40L mitochondrial import”。
The TOMM40L (N-term) antibody targets the N-terminal region of the TOMM40-like (Translocase of Outer Mitochondrial Membrane 40 Homolog) protein, a component of the mitochondrial outer membrane machinery. TOMM40L shares structural homology with TOMM40. a key subunit of the TOM complex responsible for importing nuclear-encoded proteins into mitochondria. While TOMM40 is well-characterized in mitochondrial protein translocation and linked to age-related disorders like Alzheimer’s disease (due to its proximity to the APOE gene), TOMM40L’s specific biological role remains less defined. It is hypothesized to participate in mitochondrial membrane organization or protein transport, potentially compensating for or regulating TOMM40 activity.
This antibody is commonly used in research to study TOMM40L expression, localization, and interactions via techniques like Western blotting, immunofluorescence, or immunoprecipitation. Its N-terminal specificity helps distinguish TOMM40L from other TOM complex proteins, aiding in functional studies. Interest in TOMM40L has grown due to emerging associations between mitochondrial dysfunction and neurodegenerative diseases, cancer, and metabolic syndromes. However, challenges persist in elucidating its exact mechanisms, partly due to overlapping functions with TOMM40 and limited isoform-specific data. The antibody serves as a critical tool for exploring mitochondrial biology and disease pathways involving this understudied protein.
×
