Rabbit Polyclonal SERBP1 Antibody

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     Western blot analysis of lysates from A549, HepG2, MCF-7, MDA-MB-468, rat PC-12, SK-BR-3 cell line and mouse brain tissue lysate(from left to right), using SERBP1 Antibody (Center)(Cat.  #P32733).  P32733 was diluted at 1:1000 at each lane.  A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35ug per lane.    

SERBP1 (SERPINE1 mRNA-binding protein 1), also known as PAI-RBP1. is an RNA-binding protein that regulates the stability and translation of SERPINE1/PAI-1 mRNA, a key player in fibrinolysis, cellular stress responses, and cancer progression. SERBP1 is ubiquitously expressed and primarily localizes to the cytoplasm, where it interacts with target mRNAs to modulate their post-transcriptional regulation. It has been implicated in diverse cellular processes, including hypoxia adaptation, apoptosis, and cell proliferation. Dysregulation of SERBP1 is linked to tumorigenesis, particularly in glioblastoma, ovarian cancer, and colorectal cancer, where it often correlates with poor prognosis.

SERBP1 antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). Polyclonal and monoclonal antibodies targeting specific epitopes of SERBP1 are commercially available, often validated for specificity using knockdown or knockout controls. Researchers utilize these antibodies to investigate SERBP1's role in stress granule formation, mRNA metabolism, and oncogenic pathways. Additionally, they aid in exploring SERBP1's potential as a therapeutic target or biomarker in diseases like cancer and vascular disorders. Proper validation, including cross-reactivity checks and functional assays, is critical for ensuring antibody reliability in experimental settings.