| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Metaxin-2, Mitochondrial outer membrane import complex protein 2, MTX2 |
| Entrez GeneID | 10651 |
| WB Predicted band size | 29.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MTX2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 102-126 amino acids from the Central region of human MTX2. |
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以下是关于MTX2抗体的参考文献示例(注：以下内容为虚构示例，建议通过学术数据库查询真实文献)：
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1. **文献名称**：*"Development and validation of a polyclonal antibody targeting human MTX2 for mitochondrial protein analysis"*
**作者**：Chen L, et al.
**摘要**：本研究成功制备了针对人源MTX2蛋白的多克隆抗体，并通过Western blot和免疫荧光验证其特异性。抗体用于检测线粒体中MTX2的表达动态，揭示其在氧化应激条件下表达显著升高。
2. **文献名称**：*"MTX2 modulates cellular apoptosis: Insights from antibody-based functional studies"*
**作者**：Kim H, et al.
**摘要**：利用MTX2特异性抗体进行免疫沉淀和共定位分析，发现MTX2通过与Bcl-2家族蛋白相互作用调控凋亡通路。抗体在多种癌细胞系中验证了MTX2的亚细胞定位。
3. **文献名称**：*"A novel monoclonal antibody reveals MTX2 overexpression in colorectal cancer progression"*
**作者**：Wang X, et al.
**摘要**：研究开发了一种高特异性MTX2单克隆抗体，并用于组织微阵列分析。结果显示MTX2在结直肠癌中高表达，且与转移和化疗耐药性相关，提示其作为潜在生物标志物。
4. **文献名称**：*"MTX2 antibody application in neuronal development models"*
**作者**：Gupta R, et al.
**摘要**：通过MTX2抗体介导的抑制实验，研究证实MTX2在神经元轴突生长中起关键作用。抗体用于斑马鱼模型，证明MTX2缺失导致神经发育缺陷。
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建议通过 **PubMed** 或 **Google Scholar** 输入关键词“MTX2 antibody”、“MTX2 immunolocalization”等获取真实文献。
The MTX2 antibody targets the Metaxin-2 (MTX2) protein, a mitochondrial outer membrane component involved in protein import and mitochondrial function. MTX2. part of the metaxin family alongside MTX1. facilitates the transport of nuclear-encoded proteins into mitochondria, contributing to mitochondrial integrity, metabolism, and apoptosis regulation. It interacts with MTX1 and other translocase complexes (e.g., TOMM, TIMM) to maintain mitochondrial dynamics and cellular energy balance.
MTX2 antibodies are essential tools for studying mitochondrial biology, enabling detection of MTX2 expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help explore MTX2's role in diseases linked to mitochondrial dysfunction, including neurodegenerative disorders (e.g., Parkinson’s, Alzheimer’s), cancer (due to altered metabolism), and rare genetic conditions.
Produced in hosts like rabbits or mice, MTX2 antibodies vary by clonality (monoclonal/polyoclonal) and epitope specificity. Their applications extend to elucidating MTX2's interaction networks, tissue-specific expression patterns, and responses to stressors like oxidative damage. Recent studies also investigate MTX2's potential as a biomarker or therapeutic target in pathologies involving mitochondrial impairment.
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