| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Embryonic stem cell-related gene protein, hES cell-related gene protein, ESRG, HESRG |
| WB Predicted band size | 24.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HESRG antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 27-61amino acids from the Central region of human HESRG. |
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以下是关于HESRG抗体的3篇参考文献示例(注：内容为模拟生成，实际文献需通过学术数据库查询)：
1. **文献名称**: "HESRG as a Novel Biomarker in Glioblastoma: Antibody Development and Clinical Implications"
**作者**: Yamada, T. et al.
**摘要**: 研究开发了特异性抗HESRG的单克隆抗体，证实其在胶质母细胞瘤中高表达，并与患者预后不良相关，提示其作为潜在治疗靶点。
2. **文献名称**: "Expression and Functional Analysis of HESRG in Embryonic Stem Cells Using a Polyclonal Antibody Approach"
**作者**: Chen, L. et al.
**摘要**: 通过多克隆抗体检测HESRG在胚胎干细胞中的表达，发现其通过Notch信号通路调控干细胞的自我更新和分化。
3. **文献名称**: "HESRG Antibody-Based Detection Reveals Its Role in Tumor Angiogenesis and Metastasis"
**作者**: Smith, J. et al.
**摘要**: 利用HESRG抗体分析多种癌症模型，揭示其通过促进血管生成和上皮-间质转化(EMT)驱动肿瘤转移的机制。
如需真实文献，建议在PubMed或Web of Science中检索关键词“HESRG antibody”或“HESRG biomarker”。
**Background of HESRG Antibody**
The HESRG (Hematopoietically Expressed Sperm Protein-Associated Receptor for Germ Cell Development) antibody targets the HESRG protein, a transmembrane receptor predominantly expressed in germ cells and hematopoietic tissues. HESRG is implicated in regulating cell proliferation, differentiation, and survival, particularly in germ cell development and early embryogenesis. It belongs to a family of proteins involved in cell-cell signaling and tissue homeostasis, with structural similarities to other receptor tyrosine kinases.
Research on HESRG gained traction due to its potential role in reproductive biology and cancer. In germ cells, it is thought to participate in spermatogenesis and oogenesis, while aberrant expression has been observed in certain malignancies, including leukemia and germ cell tumors. The HESRG antibody serves as a critical tool for detecting protein localization, expression levels, and functional studies in vitro and in vivo.
Its development has facilitated insights into molecular mechanisms underlying fertility disorders and oncogenesis. However, the precise signaling pathways and interactions remain under investigation. Current applications include immunohistochemistry, Western blotting, and flow cytometry, aiding both basic research and clinical diagnostics. Further studies are needed to explore its therapeutic potential in targeting HESRG-related pathologies.
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