Rabbit Polyclonal ZDHHC14 Antibody

The ZDHHC14 antibody is a research tool designed to detect and study the ZDHHC14 protein, a member of the ZDHHC family of palmitoyltransferases. These enzymes catalyze protein palmitoylation, a post-translational modification critical for regulating protein localization, stability, and interactions. ZDHHC14 is implicated in diverse cellular processes, including membrane trafficking, signal transduction, and potentially disease pathways, though its specific substrates and biological roles remain less characterized compared to other ZDHHC members. The antibody is commonly used in techniques like Western blotting, immunofluorescence, or immunohistochemistry to analyze ZDHHC14 expression patterns across tissues or cell types. Its development often involves immunizing animals with peptide antigens derived from conserved or unique regions of the protein. Researchers rely on this antibody to explore ZDHHC14's involvement in pathologies such as cancer, neurological disorders, or metabolic dysregulation, where aberrant palmitoylation may contribute to disease mechanisms. Validation steps, including knockout controls, are essential to confirm specificity due to potential cross-reactivity within the ZDHHC family. Commercial variants may vary in host species (e.g., rabbit, mouse) and clonality (monoclonal/polyoclonal), requiring careful selection based on experimental needs.