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Rabbit Polyclonal Human-AHCTF1(S1232) Antibody

  • 中文名: Human-AHCTF1 (S1232)抗体
  • 别    名: Protein ELYS, Embryonic large molecule derived from yolk sac, Protein MEL-28, Putative AT-hook-containing transcription factor 1, AHCTF1, ELYS, TMBS62
货号: IPDX32723
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein ELYS, Embryonic large molecule derived from yolk sac, Protein MEL-28, Putative AT-hook-containing transcription factor 1, AHCTF1, ELYS, TMBS62
Entrez GeneID25909
WB Predicted band size252.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis  antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1210-1260 amino acids from human.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Human-AHCTF1 (S1232)抗体的模拟参考文献示例(仅供学术参考,实际文献需通过数据库核实):

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1. **"AHCTF1 phosphorylation at Ser1232 regulates mitotic progression and nuclear envelope assembly"**

*Authors: Smith J, et al.*

*摘要*:本研究利用Human-AHCTF1 (S1232)特异性抗体,揭示了AHCTF1蛋白在细胞有丝分裂过程中丝氨酸1232位点的磷酸化修饰对核膜重组的关键调控作用,证实其异常磷酸化可能导致染色体分离缺陷。

2. **"Commercial Antibody Validation for AHCTF1 in Cancer Cell Models"**

*Authors: Lee H, et al.*

*摘要*:通过Western blot和免疫荧光实验,验证了Human-AHCTF1 (S1232)抗体在多种癌细胞系中的特异性,并发现AHCTF1在肿瘤组织中高表达,可能与基因组不稳定性相关。

3. **"Role of AHCTF1 in Neural Development: Insights from Knockdown and Antibody-Based Studies"**

*Authors: Garcia R, et al.*

*摘要*:使用S1232抗体进行免疫组化分析,发现AHCTF1在小鼠胚胎神经发育中广泛表达,敲低后导致神经管闭合缺陷,提示其参与神经前体细胞增殖调控。

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**注意**:以上内容为模拟生成,实际文献需通过PubMed、Google Scholar等平台检索关键词(如AHCTF1、S1232、抗体编号等)获取。若该抗体为某公司产品(如CST或Abcam),可查阅其官网提供的引用文献列表。

背景信息

Human-AHCTF1 (S1232) antibody is a monoclonal antibody specifically designed to detect the AHCTF1 protein (also known as ELYS or MSTP108) in human samples. AHCTF1. encoded by the *AHCTF1* gene, is a critical nuclear pore complex (NPC)-associated protein involved in post-mitotic nuclear envelope reassembly, spindle assembly, and chromosomal segregation during cell division. It interacts with components of the Ran GTPase system and facilitates NPC assembly by recruiting nucleoporins to chromatin. Dysregulation of AHCTF1 has been linked to mitotic defects, genomic instability, and diseases such as cancer, where its overexpression is observed in certain malignancies. The S1232 clone recognizes endogenous AHCTF1 via a specific epitope, validated for applications including Western blotting, immunofluorescence, and immunohistochemistry. This antibody aids in studying AHCTF1’s role in cell cycle regulation, nuclear structure dynamics, and its potential as a therapeutic target. Its specificity and reliability make it a valuable tool for exploring mitotic mechanisms and NPC-related pathologies.

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