| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ankyrin repeat domain-containing protein 24, ANKRD24, KIAA1981 |
| Entrez GeneID | 170961 |
| WB Predicted band size | 124.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This ANKRD24 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 296-328 amino acids from the Central region of human ANKRD24. |
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以下是关于ANKRD24抗体的3篇参考文献示例(注：ANKRD24相关研究较少，以下为模拟内容，实际文献需通过学术数据库验证)：
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1. **文献名称**: *ANKRD24 Expression in Breast Cancer: A Novel Prognostic Marker*
**作者**: Smith A, et al.
**摘要**: 本研究通过免疫组化分析ANKRD24在乳腺癌组织中的表达，发现其高表达与患者预后不良相关。研究使用兔源多克隆ANKRD24抗体(货号ABX-1023)，验证了其在肿瘤细胞核中的定位，并探讨其调控细胞增殖的潜在机制。
2. **文献名称**: *Development of a Monoclonal Antibody Against ANKRD24 for Functional Studies*
**作者**: Tanaka K, et al.
**摘要**: 报道了一种针对ANKRD24蛋白C端表位的鼠单克隆抗体的开发。通过Western blot和免疫荧光验证其特异性，并发现ANKRD24在DNA损伤应答中与p53通路存在相互作用，为癌症治疗提供新靶点。
3. **文献名称**: *ANKRD24 Regulates Neuronal Differentiation via Notch Signaling*
**作者**: Lee JH, et al.
**摘要**: 利用ANKRD24抗体(合作公司Antigenix制备)研究其在神经干细胞中的表达，发现敲低ANKRD24会抑制神经元分化，并通过调控Notch信号通路影响细胞命运决定。
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**注意**：以上文献为示例，实际研究中ANKRD24相关抗体文献可能有限。建议通过PubMed或Google Scholar以“ANKRD24 antibody”或“ANKRD24 AND (antibody OR expression)”为关键词检索最新成果。部分研究可能需结合基因功能分析间接引用抗体使用信息。
The ANKRD24 (Ankyrin Repeat Domain 24) antibody is a research tool designed to detect and study the ANKRD24 protein, a member of the ankyrin repeat-containing protein family. Ankyrin repeats are structural motifs involved in mediating protein-protein interactions, suggesting ANKRD24 may participate in diverse cellular processes such as signaling, cytoskeletal organization, or transcriptional regulation. While the precise biological role of ANKRD24 remains under investigation, emerging studies link it to cellular stress responses, apoptosis, and potentially cancer progression. For instance, ANKRD24 has been reported to interact with components of DNA repair pathways or modulate tumor suppressor activities, though detailed mechanisms require further elucidation.
ANKRD24 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable detection of ANKRD24 in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes verification of specificity via knockout cell lines or siRNA-mediated knockdown to confirm signal absence in ANKRD24-deficient samples. Researchers utilize these antibodies to explore ANKRD24 expression patterns across tissues, its subcellular localization (e.g., nuclear, cytoplasmic), and dysregulation in diseases like malignancies or neurodegenerative disorders. As interest grows in understanding ANKRD24's functional roles, its antibody serves as a critical reagent for uncovering its contributions to cellular homeostasis and pathological states.
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