| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Probable palmitoyltransferase ZDHHC11, Zinc finger DHHC domain-containing protein 11, DHHC-11, Zinc finger protein 399, ZDHHC11, ZNF399 |
| Entrez GeneID | 79844 |
| WB Predicted band size | 46.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZDHHC11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 333-368 amino acids from the C-terminal region of human ZDHHC11. |
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以下是关于ZDHHC11抗体的假设性参考文献示例(实际文献需通过学术数据库验证)：
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1. **文献名称**: "ZDHHC11-mediated palmitoylation of TLR4 regulates inflammatory signaling"
**作者**: Li, X., et al.
**摘要**: 本研究利用特异性ZDHHC11抗体，通过免疫沉淀和Western blot技术，证明ZDHHC11通过棕榈酰化修饰TLR4蛋白，调控巨噬细胞中NF-κB信号通路的激活，影响炎症反应。
2. **文献名称**: "Development and validation of a monoclonal antibody for ZDHHC11 in human tissues"
**作者**: Tanaka, M., et al.
**摘要**: 文章报道了一种高特异性ZDHHC11单克隆抗体的开发，并通过免疫组化验证其在多种组织中的表达模式，揭示ZDHHC11在肿瘤微环境中的潜在作用。
3. **文献名称**: "ZDHHC11 deficiency disrupts synaptic plasticity via antibody-based proteomic analysis"
**作者**: Wang, Y., et al.
**摘要**: 通过ZDHHC11抗体进行蛋白质组学分析，发现ZDHHC11缺失导致突触蛋白棕榈酰化异常，影响小鼠海马神经元的长时程增强(LTP)，提示其在神经疾病中的机制。
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**注意**：以上为模拟示例，实际文献需在PubMed、Google Scholar等平台检索关键词(如“ZDHHC11 antibody”、“ZDHHC11 function”)。建议结合具体研究领域(如癌症、神经科学、免疫学)进一步筛选。
The ZDHHC11 antibody is a research tool designed to detect ZDHHC11. a member of the DHHC (Asp-His-His-Cys) domain-containing protein family. These enzymes catalyze protein palmitoylation, a post-translational modification involving the addition of palmitate to cysteine residues, which regulates protein localization, stability, and interactions. ZDHHC11. encoded by the *ZDHHC11* gene in humans, is implicated in diverse cellular processes, including neuronal development, immune regulation, and membrane trafficking. Dysregulation of ZDHHC11 has been linked to diseases such as cancer, neurodevelopmental disorders, and X-linked intellectual disability, highlighting its biological and clinical relevance.
Antibodies targeting ZDHHC11 are typically developed in rabbits or mice using immunogenic peptides or recombinant protein fragments. They enable the detection and quantification of ZDHHC11 expression in tissues or cultured cells via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes knockout cell lines or siRNA-mediated knockdown to confirm specificity. Commercial ZDHHC11 antibodies are available from multiple suppliers, though performance may vary depending on epitope recognition and experimental conditions. Researchers utilize these antibodies to explore ZDHHC11's enzymatic mechanisms, substrate interactions, and roles in disease pathways, making them critical for advancing studies in palmitoylation biology and therapeutic targeting.
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