| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cadherin-20, CDH20, CDH7L3 |
| Entrez GeneID | 28316 |
| WB Predicted band size | 89.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CDH20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 amino acids from the N-terminal region of human CDH20. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于CDH20及其抗体研究方向的假设性参考文献示例(请注意，这些文献为虚构，仅用于演示格式)：
1. **文献名称**：*CDH20 N-terminal antibody development and application in colorectal cancer studies*
**作者**：Zhang Y, et al.
**摘要**：本研究开发了一种针对CDH20蛋白N端的高特异性多克隆抗体，验证了其在免疫组化及Western blot中的应用，并发现CDH20在结直肠癌组织中异常高表达，可能与肿瘤侵袭相关。
2. **文献名称**：*Role of CDH20 in neural crest cell migration revealed by antibody-mediated inhibition*
**作者**：Smith JL, et al.
**摘要**：通过使用CDH20 N端特异性单克隆抗体阻断功能实验，证实CDH20在胚胎发育中调控神经嵴细胞迁移，其缺失导致小鼠模型颅面形态异常。
3. **文献名称**：*Comparative analysis of CDH20 antibody specificity across vertebrate species*
**作者**：Tanaka K, et al.
**摘要**：系统评估了多种CDH20 N端抗体在不同物种(人、小鼠、斑马鱼)中的交叉反应性，为进化保守性研究提供工具，并揭示了跨物种功能差异。
**说明**：以上文献为示例性质，实际研究中请通过PubMed、Web of Science或抗体供应商官网(如Cell Signaling Technology、Abcam)查询真实文献。CDH20研究相对较少，建议结合“cadherin-20”或“cadherin family 20”等关键词扩展检索。
The CDH20 (N-term) antibody is designed to target the N-terminal region of cadherin-20 (CDH20), a member of the cadherin superfamily of calcium-dependent cell-cell adhesion molecules. Cadherins play critical roles in tissue morphogenesis, cell signaling, and maintaining structural integrity. CDH20. a classical type II cadherin, is characterized by extracellular cadherin (EC) domains that mediate homophilic interactions and a cytoplasmic domain that interacts with catenins to link the actin cytoskeleton. While its exact biological functions remain less characterized compared to other cadherins, CDH20 is implicated in neural development, tissue organization, and potentially cancer progression due to cadherin dysregulation in malignancies.
The CDH20 (N-term) antibody specifically recognizes the extracellular N-terminal region, enabling the detection of CDH20 in applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). This antibody is valuable for studying CDH20 expression patterns, localization, and interactions in biological samples. Validation often includes testing on recombinant proteins or cell lysates expressing CDH20 to confirm specificity. Researchers may use it to explore CDH20's role in developmental processes, neural circuitry, or disease contexts. Cross-reactivity with other cadherins should be ruled out due to structural similarities within the cadherin family. Proper controls, such as knockout validation or peptide blocking, are recommended to ensure accurate interpretation.
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