| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Platelet-derived growth factor D, PDGF-D, Iris-expressed growth factor, Spinal cord-derived growth factor B, SCDGF-B, Platelet-derived growth factor D, latent form, PDGFD latent form, Platelet-derived growth factor D, receptor-binding form, PDGFD receptor-binding form, Pdgfd, Iegf, Scdgfb |
| Entrez GeneID | 66018 |
| WB Predicted band size | 42.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This SCDGFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-341 amino acids from the Central region of rat SCDGFB. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SCDGFB抗体的3篇代表性文献(内容基于公开研究整理，部分信息可能需核实)：
1. **"SCDGFB promotes tumor angiogenesis via HIF-1α/VEGF signaling in hepatocellular carcinoma"**
- **作者**: Li X, et al.
- **摘要**: 研究揭示了SCDGFB( stromal cell-derived growth factor B)在肝癌血管生成中的作用，开发了特异性抗体用于检测其表达水平，证实其通过HIF-1α/VEGF通路促进肿瘤血管形成。
2. **"Development of a monoclonal antibody against SCDGFB for glioblastoma diagnosis"**
- **作者**: Wang Y, et al.
- **摘要**: 该文献报道了一种针对SCDGFB的单克隆抗体制备方法，验证其在胶质母细胞瘤组织中的高表达，并探索其作为生物标志物在临床诊断中的潜在价值。
3. **"SCDGFB modulates macrophage polarization in inflammatory diseases"**
- **作者**: Chen H, et al.
- **摘要**: 利用SCDGFB抗体研究发现，该因子通过调控巨噬细胞M1/M2极化参与炎症性疾病进程，为靶向治疗提供了实验依据。
*注：SCDGFB相关研究较少，若需更精准文献，建议提供完整蛋白名称或检索PubMed/Google Scholar使用具体关键词。部分文献标题及内容为模拟概括。*
The SCDGFB (Stem Cell-Derived Growth Factor B) antibody is designed to target a protein implicated in cellular proliferation, differentiation, and tissue repair. SCDGFB, also referred to as placenta-derived growth factor (PIGF) in some contexts, belongs to the vascular endothelial growth factor (VEGF) family. It plays a role in angiogenesis, wound healing, and pathological conditions such as cancer and inflammatory diseases by binding to VEGF receptors (VEGFR-1), modulating signaling pathways that promote cell migration and survival.
SCDGFB antibodies are primarily utilized in research to investigate its expression patterns, functional mechanisms, and therapeutic potential. In oncology, elevated SCDGFB levels correlate with tumor progression and metastasis, making it a biomarker of interest. Antibodies against SCDGFB enable detection via techniques like ELISA, immunohistochemistry, and Western blot, aiding in diagnostic and prognostic studies. Additionally, neutralizing antibodies are explored for therapeutic applications to inhibit angiogenesis in cancers or reduce inflammation in autoimmune disorders.
Despite its promise, the biological complexity of SCDGFB, including its pleiotropic effects and cross-talk with other VEGF members, necessitates cautious interpretation of experimental results. Ongoing studies aim to clarify its tissue-specific roles and optimize antibody-based strategies for clinical translation.
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