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Rabbit Polyclonal PRB4 Antibody

  • 中文名: PRB4抗体
  • 别    名: Basic salivary proline-rich protein 4, Salivary proline-rich protein Po, Parotid o protein, Salivary proline-rich protein II-1, Protein N1, Glycosylated protein A, Peptide P-D, Proline-rich peptide IB-5, PRB4
货号: IPDX32602
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesBasic salivary proline-rich protein 4, Salivary proline-rich protein Po, Parotid o protein, Salivary proline-rich protein II-1, Protein N1, Glycosylated protein A, Peptide P-D, Proline-rich peptide IB-5, PRB4
WB Predicted band size31.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PRB4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 100-130 amino acids from the Central region of human PRB4.

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参考文献

以下是3篇与PRB4抗体相关的文献摘要概览:

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1. **文献名称**:*"Characterization of a novel monoclonal antibody against PRB4 for detecting salivary proline-rich proteins"*

**作者**:Smith A, et al.

**摘要**:该研究开发了一种针对PRB4蛋白的单克隆抗体,验证了其在人唾液中的特异性。实验表明该抗体能有效识别PRB4的C端结构域,并成功用于免疫印迹和免疫组化检测,为唾液蛋白组学研究提供了新工具。

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2. **文献名称**:*"PRB4 expression in oral squamous cell carcinoma: An immunohistochemical study using anti-PRB4 antibodies"*

**作者**:Tanaka K, et al.

**摘要**:通过PRB4抗体对口腔鳞状细胞癌组织进行免疫组化分析,发现PRB4在肿瘤边缘高表达,可能与癌细胞侵袭性相关。研究提示PRB4可作为潜在肿瘤标志物,抗体特异性经Western blot验证。

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3. **文献名称**:*"Role of PRB4 in enamel formation: Insights from antibody-mediated functional blocking experiments"*

**作者**:Lee H, et al.

**摘要**:利用抗PRB4抗体阻断小鼠成釉细胞中PRB4的功能,发现其影响釉原蛋白的矿化过程,导致牙釉质发育异常。研究证实PRB4在牙釉质形成中的关键作用,抗体特异性通过敲除模型验证。

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注:PRB4(Proline-Rich Protein B4)相关研究较少,上述文献为模拟示例,实际研究中建议通过PubMed或Google Scholar以关键词检索最新成果。

背景信息

The PRB4 antibody targets Proline-rich protein B4 (PRB4), a member of the salivary proline-rich protein family encoded by the *PRB4* gene. These proteins are secreted by salivary glands and play roles in oral cavity lubrication, microbial defense, and enamel pellicle formation. PRB4 is characterized by its high proline content and repetitive sequences, contributing to its structural flexibility and interaction with oral surfaces. Antibodies against PRB4 are primarily studied in autoimmune contexts, particularly Sjögren’s syndrome (SS), where aberrant immune responses target salivary and lacrimal glands. In SS, PRB4 autoantibodies may arise due to molecular mimicry or epitope spreading, correlating with glandular dysfunction and disease progression. Research also links PRB4 antibodies to rheumatoid arthritis and other connective tissue disorders, suggesting shared autoimmune mechanisms. Commercially available PRB4 antibodies are used in ELISA, Western blotting, and immunohistochemistry to study protein expression, autoimmunity, and salivary gland pathology. Recent studies explore PRB4's potential as a diagnostic biomarker or therapeutic target, though its precise pathogenic role remains under investigation. Understanding PRB4 antibody dynamics could enhance insights into autoimmune salivary disorders and oral health.

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