| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ATPase family AAA domain-containing protein 2, AAA nuclear coregulator cancer-associated protein, ANCCA, ATAD2 |
| Entrez GeneID | 29028 |
| WB Predicted band size | 158.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ATAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the N-terminal region of human ATAD2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ATAD2 (N-term)抗体的3篇参考文献，按文献名称、作者及摘要内容概括列出：
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1. **文献名称**: *ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive cancers*
**作者**: Ciro, M. et al.
**摘要**: 该研究通过ATAD2 N端抗体进行免疫印迹和免疫组化，发现ATAD2在多种癌症中高表达，并与MYC协同调控靶基因，促进肿瘤细胞增殖和存活。
2. **文献名称**: *The AAA+ ATPase ATAD2 interacts with the DNA methyltransferase DNMT3B and regulates chromatin dynamics*
**作者**: Revenko, A.S. et al.
**摘要**: 利用ATAD2 (N-term)特异性抗体进行染色质免疫沉淀(ChIP)，揭示了ATAD2通过结合DNMT3B参与表观遗传调控，影响染色质重塑和基因沉默。
3. **文献名称**: *Overexpression of ATAD2 correlates with advanced tumor stage and poor prognosis in hepatocellular carcinoma*
**作者**: Zou, J.X. et al.
**摘要**: 研究采用ATAD2 N端抗体检测肝癌组织中的蛋白表达水平，发现ATAD2过表达与肿瘤分期进展和患者不良预后显著相关，提示其作为潜在生物标志物。
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以上文献均通过ATAD2 N端抗体验证其在癌症生物学中的功能及临床意义，涉及机制研究或临床相关性分析。如需具体卷期或页码，建议通过PubMed或期刊数据库进一步检索。
The ATAD2 (N-term) antibody is designed to target the N-terminal region of ATAD2 (ATPase family AAA domain-containing protein 2), a nuclear protein belonging to the AAA+ ATPase family. ATAD2. also known as ANCCA or PRO2000. is implicated in chromatin remodeling, transcriptional regulation, and cell cycle progression. It contains two conserved domains: an N-terminal bromodomain involved in acetyl-lysine recognition and a C-terminal AAA+ ATPase domain critical for its enzymatic activity. The N-terminal region is often targeted by antibodies due to its unique epitopes and functional significance in protein-protein interactions, particularly with transcription factors like MYC and estrogen receptor alpha (ERα).
ATAD2 is overexpressed in various cancers, including breast, prostate, ovarian, and lung cancers, where it correlates with poor prognosis, proliferation, and metastasis. Its role in promoting oncogenesis involves facilitating DNA replication, enhancing transcriptional activation of growth-promoting genes, and inhibiting apoptosis. The ATAD2 (N-term) antibody is widely used in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study ATAD2 expression levels, cellular localization, and interactions in both normal and pathological contexts. Its specificity for the N-terminal region ensures detection of full-length ATAD2. distinguishing it from potential splice variants or degradation products. This antibody serves as a valuable tool for exploring ATAD2's mechanisms in cancer biology and its potential as a therapeutic target.
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