Rabbit Polyclonal PLD6 Antibody

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     Western blot analysis of lysates from human ovary and mouse testis tissue lysates (from left to right),  using PLD6 Antibody (Center)(Cat.  #P32594).  P32594 was diluted at 1:1000 at each lane.  A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.  Lysates at 35ug per lane.    

The phospholipase D6 (PLD6) antibody is a research tool designed to detect and study PLD6. a member of the phospholipase D (PLD) family. PLD6. also known as mitochondrial PLD or MitoPLD, is an enzyme that catalyzes the hydrolysis of phospholipids to generate phosphatidic acid, a lipid signaling molecule. Unlike other PLD isoforms, PLD6 is primarily localized to mitochondria, where it plays critical roles in mitochondrial dynamics, including membrane fusion, mitophagy, and regulation of mitochondrial RNA metabolism. It is also implicated in germ cell development, particularly spermatogenesis, through its involvement in piRNA (PIWI-interacting RNA) biogenesis, which safeguards genome integrity by silencing transposable elements.

PLD6 antibodies are widely used in molecular and cellular biology to investigate PLD6 expression, localization, and function in various tissues and disease models. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry. Dysregulation of PLD6 has been linked to infertility, neurodegenerative disorders, and cancer, making its study clinically relevant. For instance, PLD6 mutations or altered expression are associated with defects in mitochondrial function and germ cell maturation. Researchers also explore PLD6's role in metabolic syndromes and oxidative stress responses. As an emerging tool, PLD6 antibodies contribute to elucidating mitochondrial biology and potential therapeutic targets for related pathologies.