| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Forkhead box protein N4, FOXN4 |
| Entrez GeneID | 121643 |
| WB Predicted band size | 55.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FOXN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human FOXN4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **FOXN4 (N-term) 抗体** 的3篇参考文献示例(部分信息为假设性示例，实际需根据文献调整)：
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1. **文献名称**: "FOXN4 regulates cerebellar granule cell development through transcriptional activation of specific target genes"
**作者**: Huang, Y., et al.
**摘要**: 本研究利用针对FOXN4 N端结构域的多克隆抗体(免疫原为N-term肽段)，通过Western blot和免疫组化分析，揭示了FOXN4在小脑颗粒神经元分化中的关键作用，证实其通过结合特定启动子区域调控下游基因表达。
2. **文献名称**: "FOXN4 is essential for thymic epithelial cell differentiation and postnatal thymus maintenance"
**作者**: Li, J., et al.
**摘要**: 作者使用FOXN4 (N-term)单克隆抗体进行免疫荧光染色，发现FOXN4在胸腺上皮细胞中的特异性表达，并证明其缺失导致胸腺发育异常，强调了FOXN4在T细胞成熟中的核心调控功能。
3. **文献名称**: "FOXN4 modulates β-cell function and survival in a diabetic mouse model"
**作者**: Wang, X., et al.
**摘要**: 该研究通过FOXN4 N端抗体(货号：AB123)进行胰腺组织染色及ChIP-seq分析，发现FOXN4通过调控胰岛素分泌相关基因影响β细胞功能，为糖尿病病理机制提供了新见解。
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**注意**：以上文献信息为示例，实际引用需查询具体数据库(如PubMed、Google Scholar)并核实抗体应用场景。真实文献可通过关键词“FOXN4 antibody N-terminal”或“FOXN4 immunohistochemistry”检索。
The FOXN4 (N-term) antibody is a specialized tool designed to target the N-terminal region of the FOXN4 protein, a member of the Forkhead box (FOX) family of transcription factors. FOXN4. encoded by the FOXN4 gene, plays critical roles in embryonic development and tissue-specific gene regulation, particularly in the nervous system and sensory organs. It contains a conserved forkhead DNA-binding domain near its N-terminus, which facilitates its interaction with specific DNA sequences to modulate gene expression.
This antibody is commonly used in research to detect FOXN4 expression in various experimental models via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal region ensures recognition of full-length FOXN4 while minimizing cross-reactivity with truncated isoforms or related FOX proteins. Researchers employ it to study FOXN4's involvement in developmental pathways, cellular differentiation, and disease mechanisms, such as neurodevelopmental disorders or cancers where FOXN4 dysregulation has been implicated.
Studies suggest FOXN4 may interact with other transcriptional regulators to maintain tissue homeostasis, though its precise molecular mechanisms remain under investigation. The antibody's utility extends to both basic and translational research, aiding in the exploration of FOXN4's functional diversity and potential therapeutic targets. Proper validation, including knockout controls, is essential to confirm its specificity in experimental settings.
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