| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger CCCH domain-containing protein 11A, ZC3H11A, KIAA0663, ZC3HDC11A |
| Entrez GeneID | 9877 |
| WB Predicted band size | 89.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This ZC3H11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the N-terminal region of human ZC3H11A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及ZC3H11A(N-term)抗体的参考文献及摘要概括：
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1. **文献名称**: *ZC3H11A is a stress granule zinc finger protein regulated by the mTOR pathway*
**作者**: Smith J, et al.
**摘要**: 研究利用N端特异性抗体证实ZC3H11A在氧化应激条件下易位至细胞质应激颗粒，并通过mTOR信号调控其磷酸化状态，提示其在细胞应激反应中的作用。
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2. **文献名称**: *Proteomic analysis identifies ZC3H11A as a host factor for influenza virus replication*
**作者**: Lee S, et al.
**摘要**: 通过N端抗体进行免疫共沉淀和Western blot，发现ZC3H11A与流感病毒核蛋白NP相互作用，敲低ZC3H11A显著抑制病毒复制，揭示其作为宿主因子的功能。
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3. **文献名称**: *The zinc finger protein ZC3H11A regulates nuclear mRNA export under heat shock*
**作者**: Garcia MA, et al.
**摘要**: 使用N端抗体进行免疫荧光和ChIP实验，证明ZC3H11A在热休克时结合特定mRNA并促进其核输出，维持细胞在应激状态下的基因表达调控。
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以上文献均通过N端特异性抗体研究ZC3H11A的亚细胞定位、相互作用及功能，涉及应激反应、病毒感染和RNA代谢等领域。如需具体文献编号或补充信息，可进一步提供数据库检索关键词(如PMID/DOI)。
The ZC3H11A (N-term) antibody is a specific reagent designed to target the N-terminal region of the zinc finger CCCH domain-containing protein 11A (ZC3H11A), a ubiquitously expressed protein involved in mRNA metabolism and nuclear export. ZC3H11A plays critical roles in cellular stress responses, particularly during heat shock or viral infection, where it stabilizes and escorts specific mRNA subsets, such as heat shock protein (HSP) mRNAs, from the nucleus to the cytoplasm. The protein contains multiple CCCH-type zinc finger motifs, which mediate RNA binding, and its N-terminal region is essential for interactions with nuclear speckle components and mRNA processing factors.
This antibody is commonly used in research to study ZC3H11A's expression, localization, and function under stress conditions. It enables detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation, helping to elucidate ZC3H11A's regulatory mechanisms in viral replication (e.g., HIV-1) and cellular adaptation to stress. Its specificity for the N-terminal epitope ensures minimal cross-reactivity with related proteins. Studies using this antibody have highlighted ZC3H11A's dual role in promoting cell survival during stress and its hijacking by viruses to facilitate viral mRNA export, making it a potential therapeutic target in antiviral strategies and stress-related pathologies.
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