| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3 |
| Entrez GeneID | 657 |
| WB Predicted band size | 60.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-196 amino acids from the C-terminal region of human BMPR1A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于BMPR1A抗体的示例参考文献(注：以下为构造示例，实际文献需通过学术数据库查询)：
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1. **文献名称**: *"BMPR1A Expression in Colorectal Cancer: Correlation with Clinicopathological Features"*
**作者**: Smith A, et al.
**摘要**: 本研究通过免疫组化(IHC)分析BMPR1A蛋白在结直肠癌组织中的表达，发现其低表达与患者预后不良显著相关，提示BMPR1A可能作为潜在的肿瘤抑制标志物。
2. **文献名称**: *"Germline BMPR1A Mutations Detected by Immunohistochemistry in Juvenile Polyposis Syndrome"*
**作者**: Johnson R, et al.
**摘要**: 利用BMPR1A特异性抗体对幼年性息肉病综合征(JPS)患者组织样本进行检测，验证了BMPR1A基因突变导致的蛋白表达缺失，为遗传筛查提供辅助诊断工具。
3. **文献名称**: *"BMPR1A Antibody Validation for Western Blot and Flow Cytometry Applications"*
**作者**: Lee C, et al.
**摘要**: 本研究系统评估了多种BMPR1A抗体的特异性与灵敏度，确认某商业化抗体在Western blot和流式细胞术中可靠检测细胞系及原代细胞中的BMPR1A蛋白。
4. **文献名称**: *"Role of BMPR1A in TGF-β/BMP Signaling Pathway Regulation"*
**作者**: Wang Y, et al.
**摘要**: 通过敲低BMPR1A并结合抗体检测，揭示其在调控SMAD磷酸化及成骨分化中的关键作用，为骨代谢疾病机制研究提供依据。
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如需实际文献，建议检索PubMed或Google Scholar，使用关键词“BMPR1A antibody”、“BMPR1A immunohistochemistry”或结合具体研究领域(如癌症、信号通路)。
The BMPR1A antibody targets Bone Morphogenetic Protein Receptor Type 1A, a transmembrane serine/threonine kinase belonging to the TGF-β receptor superfamily. BMPR1A plays a critical role in the BMP signaling pathway, regulating cellular processes such as proliferation, differentiation, and apoptosis. It binds BMP ligands via its extracellular domain, initiating downstream signaling through SMAD proteins or non-canonical pathways. Mutations in the BMPR1A gene are linked to juvenile polyposis syndrome (JP), a hereditary condition predisposing individuals to gastrointestinal polyps and cancer, underscoring its importance in tissue homeostasis and disease.
BMPR1A antibodies are essential tools in biomedical research, used to study receptor expression, localization, and signaling activity. They enable detection via techniques like Western blot, immunohistochemistry, and flow cytometry. Specific clones may recognize epitopes in the extracellular, intracellular, or kinase domains, with applications spanning cancer research, developmental biology, and genetic disorder diagnostics. Validated antibodies help assess BMPR1A dysregulation in tumors or validate gene-editing outcomes. Commercial antibodies often specify reactivity across species (human, mouse, rat) and require validation for target specificity to minimize cross-reactivity. Research using BMPR1A antibodies continues to clarify its role in development, disease mechanisms, and therapeutic targeting.
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