| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 41, ZNF41 |
| Entrez GeneID | 7592 |
| WB Predicted band size | 93.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human ZNF41. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF41 (N-term)抗体的3篇参考文献示例(内容基于虚构，建议通过学术数据库验证)：
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1. **文献名称**: "Characterization of a Novel ZNF41 N-terminal Antibody for Epigenetic Studies"
**作者**: Smith A, et al.
**摘要**: 本研究开发并验证了一种针对ZNF41蛋白N端结构域的高特异性多克隆抗体。通过Western blot和免疫荧光实验证实其在人细胞系中检测内源性ZNF41的能力，并应用于染色质免疫沉淀(ChIP)分析，揭示ZNF41在X染色体基因调控中的作用。
2. **文献名称**: "ZNF41 N-terminal Variants and Their Role in Intellectual Disability"
**作者**: Johnson R, et al.
**摘要**: 文章利用ZNF41 (N-term)抗体探究了该蛋白N端突变与智力障碍的关联。通过患者样本分析，发现特定截短突变导致ZNF41核定位异常，抗体在免疫组化中有效区分突变体与野生型蛋白，支持其作为诊断工具的潜力。
3. **文献名称**: "Zinc Finger Protein 41 Interactions Revealed by N-terminal Epitope Tagging"
**作者**: Lee C, et al.
**摘要**: 研究通过CRISPR/Cas9技术构建ZNF41 N端表位标记细胞系，结合商业ZNF41 (N-term)抗体进行共免疫沉淀，鉴定出与转录抑制复合物(如NuRD)的相互作用，提示其在表观遗传沉默中的功能。
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**建议**：通过PubMed或Google Scholar搜索关键词“ZNF41 antibody N-terminal”或“ZNF41 epitope mapping”获取真实文献。部分抗体供应商(如Abcam、Thermo Fisher)的产品说明书也可能提供引用文献。
The ZNF41 (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the N-terminal region of the Zinc Finger Protein 41 (ZNF41), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF41 is encoded by a gene located on the X chromosome (Xp11.3) and is implicated in transcriptional regulation, chromatin remodeling, and epigenetic modifications through its interaction with DNA and protein complexes. The N-terminal region of ZNF41 typically contains a KRAB domain, which mediates interactions with co-repressors like TRIM28/KAP1 to recruit histone-modifying enzymes, leading to gene silencing.
This antibody is commonly used in research applications such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study ZNF41's expression, localization, and functional mechanisms. Its specificity for the N-terminal region ensures recognition of full-length ZNF41 or isoforms retaining this domain, aiding in distinguishing ZNF41 from related zinc finger proteins. Studies utilizing this antibody have linked ZNF41 to neurodevelopmental processes and X-linked intellectual disability, as mutations or dysregulation of ZNF41 are associated with cognitive impairments and developmental disorders. Researchers also employ it to explore ZNF41's role in gene regulatory networks, particularly in stem cell differentiation and cellular response pathways. Validation data, including knockout controls or peptide-blocking assays, are often provided to confirm antibody specificity.
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