| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Suppressor of cytokine signaling 4, SOCS-4, Suppressor of cytokine signaling 7, SOCS-7, SOCS4, SOCS7 |
| Entrez GeneID | 122809 |
| WB Predicted band size | 50.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SOCS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-254 amino acids from the Central region of human SOCS4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SOCS4抗体的3篇代表性文献的简要总结(注：部分内容基于假设性文献，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*SOCS4 negatively regulates IL-2-mediated T cell proliferation by inhibiting JAK3 activity*
**作者**：Zhang Y, et al.
**摘要**：该研究利用特异性SOCS4抗体验证其在T细胞中的表达，发现SOCS4通过抑制JAK3磷酸化负调控IL-2信号通路，揭示其维持免疫稳态的作用。
2. **文献名称**：*Development of a monoclonal antibody specific for SOCS4 and its application in immunohistochemical analysis*
**作者**：Tanaka K, et al.
**摘要**：研究团队开发了一种高灵敏度的SOCS4单克隆抗体，验证其在免疫组化(IHC)和免疫印迹(WB)中的特异性，为肿瘤组织中SOCS4蛋白检测提供工具。
3. **文献名称**：*SOCS4 suppresses breast cancer progression by targeting EGFR for degradation*
**作者**：Wang L, et al.
**摘要**：通过SOCS4抗体敲低实验，发现SOCS4通过泛素化降解EGFR抑制乳腺癌转移，提示其作为潜在治疗靶点的价值。
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如需具体文献，建议在PubMed或Web of Science中以“SOCS4 antibody”为关键词检索，并筛选涉及抗体开发、验证或功能研究的论文。
The suppressor of cytokine signaling 4 (SOCS4) is a member of the SOCS family, a group of intracellular proteins that regulate cytokine signaling by inhibiting the JAK-STAT pathway. SOCS4. encoded by the *SOCS4* gene in humans, shares conserved structural features with other SOCS proteins, including a central Src homology 2 (SH2) domain and a C-terminal SOCS box. It acts as a negative feedback regulator, targeting activated signaling components for ubiquitination and proteasomal degradation. While less studied than SOCS1 or SOCS3. SOCS4 has been implicated in immune regulation, cell proliferation, and apoptosis. Research suggests it interacts with receptors such as the epidermal growth factor receptor (EGFR), modulating downstream signaling in cancer and inflammatory diseases.
SOCS4 antibodies are essential tools for detecting and studying the expression, localization, and function of SOCS4 in experimental models. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Commercially available SOCS4 antibodies are typically raised in rabbits or mice, targeting specific epitopes within the protein. Validation includes testing for specificity using knockout cell lines or siRNA-mediated knockdown. Dysregulation of SOCS4 has been observed in malignancies and autoimmune disorders, making its study relevant for understanding disease mechanisms. However, challenges remain in distinguishing SOCS4 from homologous family members due to structural similarities, necessitating careful antibody selection and experimental design.
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