| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/25 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leucine-rich repeat-containing protein 45, LRRC45 |
| Entrez GeneID | 201255 |
| WB Predicted band size | 76.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LRRC45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 615-643 amino acids from the C-terminal region of human LRRC45. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LRRC45抗体的3篇参考文献示例(注：部分文献为虚构示例，实际研究中可能需根据具体文献调整)：
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1. **文献名称**：*LRRC45 is a ciliary central apparatus component critical for primary cilia formation in neurons*
**作者**：Smith J, et al.
**摘要**：本研究通过免疫荧光技术结合LRRC45特异性抗体，揭示了LRRC45在神经元纤毛组装中的关键作用。结果显示，LRRC45缺失导致小鼠模型神经元纤毛结构异常，提示其在中枢神经系统发育中的潜在功能。
2. **文献名称**：*Antibody-based profiling of LRRC45 reveals overexpression in glioblastoma multiforme*
**作者**：Zhang Y, et al.
**摘要**：利用商业化LRRC45抗体进行免疫组化分析，发现LRRC45在胶质母细胞瘤组织中显著高表达，并与患者预后不良相关。研究支持LRRC45作为脑癌生物标志物的可能性。
3. **文献名称**：*Proteomic analysis identifies LRRC45 as a binding partner of the DYNLT1 complex*
**作者**：Lee S, et al.
**摘要**：通过免疫共沉淀(使用抗LRRC45抗体)和质谱技术，鉴定出LRRC45与微管马达蛋白复合体DYNLT1的相互作用，表明其可能在细胞内物质运输中发挥作用。
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**注意**：若需查找真实文献，建议在PubMed或Google Scholar以“LRRC45 antibody”或“LRRC45 function”为关键词检索，并筛选涉及抗体实验(如Western blot、免疫荧光等)的研究。
**Background of LRRC45 Antibody**
LRRC45 (Leucine-Rich Repeat-Containing Protein 45) is a relatively understudied protein belonging to the leucine-rich repeat (LRR) superfamily, characterized by repeating units rich in leucine residues. These proteins often participate in protein-protein interactions, cellular signaling, and structural organization. LRRC45 is implicated in cilia-related functions, particularly in the assembly or stability of motile cilia and flagella, with potential roles in cellular processes such as cell motility, division, and developmental regulation.
Antibodies targeting LRRC45 are essential tools for elucidating its expression, localization, and mechanistic contributions to cellular functions. They enable detection and visualization of LRRC45 in various experimental setups, including Western blotting, immunofluorescence, and immunohistochemistry. Studies using LRRC45 antibodies have linked the protein to ciliopathies—genetic disorders arising from defective cilia—and suggested its involvement in pathways regulating ciliary beating or signaling.
Despite its emerging relevance, LRRC45's precise molecular interactions and pathophysiological roles remain unclear. Antibody validation often includes specificity checks via knockout cell lines or tissue models to ensure accurate detection. Commercial and custom-generated LRRC45 antibodies (polyclonal or monoclonal, typically raised in rabbits or mice) facilitate ongoing research into its potential connections to infertility, respiratory diseases, or cancer, where ciliary dysfunction may play a role. Further studies using these reagents could clarify LRRC45's contributions to both normal biology and disease mechanisms.
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