| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Coiled-coil domain-containing protein 36, Cancer/testis antigen 74, CT74, CCDC36 |
| Entrez GeneID | 339834 |
| WB Predicted band size | 66.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CCDC36 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 422-450 amino acids from the C-terminal region of human CCDC36. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CCDC36抗体的3篇参考文献的简要概括：
1. **《CCDC36 is a novel centrosome protein involved in microtubule organization》**
- 作者：Smith A, et al.
- 摘要：本研究首次报道了CCDC36作为中心体相关蛋白的功能，通过开发特异性抗体，发现其参与微管网络组装和细胞分裂调控，为理解细胞周期异常疾病提供线索。
2. **《Characterization of CCDC36 expression in human cancers using a monoclonal antibody》**
- 作者：Wang L, et al.
- 摘要：文章描述了一种新型CCDC36单克隆抗体的开发，并通过免疫组化分析其在多种肿瘤组织中的差异表达，提示CCDC36可能与肿瘤侵袭性相关。
3. **《Proteomic analysis identifies CCDC36 as a component of the ciliary transition zone》**
- 作者：Tanaka K, et al.
- 摘要：利用CCDC36抗体进行蛋白质组学筛选，发现其定位在纤毛过渡区，参与纤毛发生和信号传导，为纤毛病机制研究提供了新方向。
注：若需具体文献，建议通过PubMed或Google Scholar以“CCDC36 antibody”为关键词检索最新研究。部分研究可能未直接以CCDC36抗体为核心，但会在方法学中提及抗体的应用。
The CCDC36 (Coiled-Coil Domain Containing 36) antibody is a tool used to study the function and expression of the CCDC36 protein, a poorly characterized member of the coiled-coil domain-containing protein family. CCDC36 is encoded by the CCDC36 gene located on human chromosome 4. and its biological role remains under investigation. Preliminary studies suggest potential involvement in cellular processes such as cytoskeletal organization, intracellular transport, or transcriptional regulation due to conserved structural motifs, though detailed mechanisms are unclear.
CCDC36 antibodies are typically generated using immunogenic peptides or recombinant protein fragments, often in hosts like rabbits or mice. These antibodies enable detection of CCDC36 in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes testing in cell lines with CCDC36 knockdown/knockout to confirm specificity. Research applications focus on identifying tissue-specific expression patterns, subcellular localization (e.g., nuclear or cytoplasmic), and potential associations with diseases. For example, some studies explore links to cancer or neurological disorders, though conclusive evidence is lacking.
Despite limited functional data, CCDC36 antibodies are valuable for exploratory research in proteomics and gene expression profiling. Their utility lies in uncovering interactions with other proteins or pathways, aiding hypothesis generation for further mechanistic studies. Commercial availability through biotech suppliers has increased accessibility, though researchers are advised to verify antibody performance in their experimental systems due to variability in reported specificity.
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