| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Low-density lipoprotein receptor-related protein 12, LRP-12, Suppressor of tumorigenicity 7 protein, LRP12, ST7 |
| Entrez GeneID | 29967 |
| WB Predicted band size | 95.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LRP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 635-662 amino acids from the C-terminal region of human LRP12. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LRP12抗体的虚构示例参考文献(实际文献需通过学术数据库查询)：
1. **文献名称**: "LRP12 Antibody Development for Studying Wnt Signaling in Cancer"
**作者**: Chen H, et al.
**摘要**: 该研究开发了针对LRP12蛋白的高特异性单克隆抗体，并验证其在结直肠癌细胞系中通过调控Wnt/β-catenin信号通路抑制肿瘤增殖的机制。
2. **文献名称**: "Characterization of LRP12 Expression in Neurodegenerative Disorders Using Novel Polyclonal Antibodies"
**作者**: Martinez R, et al.
**摘要**: 通过新型多克隆抗体检测LRP12在阿尔茨海默病和帕金森病患者脑组织中的表达水平，发现其与tau蛋白异常聚集存在相关性。
3. **文献名称**: "LRP12 Antibody-Based Screening Reveals Its Role in Lipid Metabolism"
**作者**: Wang Y, et al.
**摘要**: 利用抗LRP12抗体进行高通量筛选，发现其在肝脏细胞中通过调节LDL受体活性影响脂质代谢，为代谢综合征研究提供新靶点。
4. **文献名称**: "Structural Analysis of LRP12 Extracellular Domain Using Domain-Specific Antibodies"
**作者**: Lee S, et al.
**摘要**: 通过针对LRP12胞外结构域的特异性抗体进行冷冻电镜研究，解析其三维结构并揭示与配体结合的关键表位。
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**注意**：以上内容为示例性虚构文献，真实文献请通过PubMed、Google Scholar等平台检索关键词"LRP12 antibody"或"LRP12 function"。
The LRP12 antibody targets the LDL Receptor-Related Protein 12 (LRP12), a transmembrane protein belonging to the low-density lipoprotein receptor (LDLR) family. LRP12. also known as ST7R or LRPD3. is characterized by multiple ligand-binding EGF-like domains and a cytoplasmic tail involved in intracellular signaling. While its precise biological functions remain under investigation, LRP12 is implicated in regulating cellular processes such as adhesion, migration, and receptor-mediated endocytosis. Studies suggest its role in modulating Wnt/β-catenin and other signaling pathways, potentially influencing tumor suppression or progression depending on cellular context.
LRP12 has been linked to diseases, including cancers (e.g., hepatocellular carcinoma, lung cancer) and neurodevelopmental disorders. Antibodies against LRP12 are essential tools for detecting its expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or flow cytometry. They help elucidate its localization, interaction partners, and dysregulation in pathological conditions. Recent research also explores LRP12’s involvement in viral entry mechanisms, highlighting its broader biomedical relevance. Commercial LRP12 antibodies are typically monoclonal or polyclonal, validated for specificity across human and model organisms. Ongoing studies aim to clarify its therapeutic potential as a biomarker or drug target.
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