| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AMP deaminase 3, AMP deaminase isoform E, Erythrocyte AMP deaminase, AMPD3 |
| Entrez GeneID | 272 |
| WB Predicted band size | 88.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This AMPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-356 amino acids from the Central region of human AMPD3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及AMPD3抗体的代表性文献(虚构示例，仅供格式参考)：
1. **文献名称**：*AMPD3 Deficiency Induces Erythrocyte Dysfunction via Purine Metabolism Imbalance*
**作者**：Smith J, et al.
**摘要**：通过AMPD3特异性抗体检测发现，AMPD3基因敲除小鼠的红细胞中腺苷代谢异常，导致细胞膜脆性增加，揭示了AMPD3在维持红细胞稳态中的作用。
2. **文献名称**：*Immunohistochemical Analysis of AMPD3 in Human Bone Marrow Disorders*
**作者**：Chen L, et al.
**摘要**：利用抗AMPD3单克隆抗体对骨髓样本进行染色，发现再生障碍性贫血患者中AMPD3蛋白表达显著下调，提示其可作为疾病诊断的生物标志物。
3. **文献名称**：*Development of a High-Affinity AMPD3 Antibody for Proteomic Profiling*
**作者**：Wang Y, et al.
**摘要**：报道了一种新型兔源多克隆抗体的制备与验证，该抗体通过ELISA/WB/IF实验证实对AMPD3具有高特异性，成功应用于癌症细胞系的蛋白质互作组学研究。
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**注意**：以上文献为模拟示例，实际文献需通过PubMed/Google Scholar检索关键词"AMPD3 antibody"或"anti-AMPD3"获取。建议使用科研数据库查询真实研究。
The AMPD3 (adenosine monophosphate deaminase 3) antibody is a tool used to detect and study the AMPD3 protein, an enzyme encoded by the AMPD3 gene in humans. AMPD3 plays a critical role in purine metabolism by catalyzing the deamination of adenosine monophosphate (AMP) to inosine monophosphate (IMP), a reaction essential for maintaining cellular energy balance and nucleotide pool homeostasis. This enzyme is predominantly expressed in hematopoietic tissues, particularly in erythrocytes (red blood cells) and lymphocytes, where it regulates ATP levels and influences cell viability under metabolic stress.
AMPD3 antibodies are widely utilized in research to investigate the enzyme's function in physiological and pathological contexts. For instance, studies focus on its role in erythrocyte disorders, such as anemia, malaria susceptibility, and sickle cell disease, where altered AMPD3 activity may impact red cell survival and disease progression. Additionally, AMPD3 dysfunction has been linked to metabolic syndromes and immune system irregularities.
These antibodies are employed in techniques like Western blotting, immunohistochemistry, and flow cytometry to quantify AMPD3 expression, assess tissue-specific distribution, and explore its interactions with other cellular components. Understanding AMPD3's mechanisms through antibody-based research provides insights into potential therapeutic targets for blood-related and metabolic disorders.
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